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    almost4years
    Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression. (PubMed, Oncol Rep)
    Moreover, NSC‑631570 suppressed the growth of all tested HNSCC cell lines, including a paclitaxel‑resistant and P‑glycoprotein (MDR1)‑overexpressing cell line. In addition, NSC‑631570 showed a high anti‑angiogenic action on the tube formation ability of human umbilical vein endothelial cells (HUVECs). In conclusion, this study highlights NSC‑631570 as a promising therapeutic approach for HNSCC.
    Journal
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    EGFR (Epidermal growth factor receptor) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • JAK1 (Janus Kinase 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1)
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    paclitaxel • Ukrain (NSC B238865)