TY 101

The molecular docking study revealed that BCL-XL has a higher binding affinity with the most active compounds, and the MD simulation showed that some residues of the BH3 domain, such as Phe97, Tyr101, Arg102, and Phe105 create remarkable hydrophobic interactions with the ligands. 3D-QSAR study is a beneficial method to evaluate and design anticancer compounds. Considering the results of the molecular docking study, MD simulation, and ADME/T analysis, the designed compound 54 could be considered as a potential treatment for glioblastoma.

The result also suggested that the effect of TY101 was similar to that of anti-PD-L1 when used in combination with these immunostimulants. Therefore, we propose that treatment strategies of antagonizing TNFR2 on Tregs would behave as potent checkpoint inhibitors and can potentially be utilized to develop a novel antitumor immunotherapy.

P1/2, N=268, Recruiting, Tayu Huaxia Biotech Medical Group Co., Ltd. | Not yet recruiting --> Recruiting | Initiation date: Aug 2020 --> Dec 2020

The most common mutations of protein change was p.Thr96Ser (20.5%), followed by p.Tyr101* (14.5%) and p.Lys322Asn (2.6%), which mainly occurred in exon 2 (2/7) and exon7 (7/7)...Legal entity responsible for the study: Inner Mongolia People's Hospital. Funding: Has not received any funding.

P1/2, N=268, Not yet recruiting, Tayu Huaxia Biotech Medical Group Co., Ltd.