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DRUG:

Zynyz (retifanlimab-dlwr)

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Company:

Incyte, MacroGenics

Drug class:

PD1 inhibitor

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Undisclosed anti PD-1 mAb (0)

anti-PD-1 antibody (0)

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No biomarker	Merkel Cell Carcinoma	No biomarker	Merkel Cell Carcinoma	retifanlimab-dlwr Sensitive: A1 - Approval retifanlimab-dlwr Sensitive : A1	retifanlimab-dlwr Sensitive: A1 - Approval retifanlimab-dlwr Sensitive : A1
MSI-H/dMMR	Endometrial Cancer	MSI-H/dMMR	Endometrial Cancer	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2
PD-L1 expression	Urothelial Cancer	PD-L1 expression	Urothelial Cancer	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2
PD-L1 overexpression	Non Small Cell Lung Cancer	PD-L1 overexpression	Non Small Cell Lung Cancer	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2	retifanlimab-dlwr Sensitive: C2 – Inclusion Criteria retifanlimab-dlwr Sensitive : C2
HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	margetuximab + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab + retifanlimab-dlwr Sensitive : C3	margetuximab + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab + retifanlimab-dlwr Sensitive : C3
IDH wild-type	Glioblastoma	IDH wild-type	Glioblastoma	bevacizumab + retifanlimab-dlwr Sensitive: C3 – Early Trials bevacizumab + retifanlimab-dlwr Sensitive : C3	bevacizumab + retifanlimab-dlwr Sensitive: C3 – Early Trials bevacizumab + retifanlimab-dlwr Sensitive : C3