Catharanthus roseus is an important medicinal plant and the only source of the important anticancer compounds vincristine and vinblastine. Ascorbate peroxidase activity generally decreased below control levels, except in 4% CE for 78 h its activity increased slightly and reached the control levels. In conclusion, our results show that CF demonstrates a stronger elicitor than CE, particularly at higher concentrations and longer exposure, for inducing defense responses in C. roseus cell suspension culture.

Genetic or pharmacological inhibition of IRE1α or spliced XBP1 (sXBP1) suppresses cell proliferation, promotes terminal myogenic differentiation, and enhances vincristine-induced cytotoxicity in RMS cells...Consistently, inducible knockdown of sXBP1 or pharmacological inhibition of IRE1α endonuclease activity significantly attenuates xenograft RMS growth. Collectively, these findings identify the IRE1α-XBP1 axis as a critical regulator of RMS growth, differentiation, and chemosensitivity, and support its therapeutic targeting in RMS.

Genetic or pharmacological inhibition of IRE1α or spliced XBP1 (sXBP1) suppresses cell proliferation, promotes terminal myogenic differentiation, and enhances vincristine-induced cytotoxicity in RMS cells...Consistently, inducible knockdown of sXBP1 or pharmacological inhibition of IRE1α endonuclease activity significantly attenuates xenograft RMS growth. Collectively, these findings identify the IRE1α-XBP1 axis as a critical regulator of RMS growth, differentiation, and chemoresistance, and support its therapeutic targeting in RMS.

To examine the involvement of centrosome clustering in the mechanism by which BATF2 reverses MDR in GC, adriamycin (ADR)- and vincristine (VCR)-resistant cell lines, NCI-N87/ADR and NCI-N87/VCR, were used for investigations. Meanwhile, KU-60019, a specific inhibitor of ATM, could markedly reverse the pro-tumor effects of BATF2 knockdown. In conclusion, BATF2 is a potential target for reversing MDR in GC, and targeting KIFC1-related centrosome clustering by suppressing ATM phosphorylation is proposed as a key mechanism.

This study evaluated the antitumor and chemopreventive efficacy of Pleurotus ostreatus ethanolic extract (PoEE), compared with vincristine, a standard anticancer drug, in a 7,12-dimethylbenz(α)anthracene (DMBA) and N-methyl Urea (NMU) BC model using female Sprague-Dawley rats (n = 64)...This dysregulation was accompanied by decreased antioxidant enzyme activity (SOD -26.7%, CAT -27.2%) and hormonal imbalance (estradiol -23.9%, progesterone -11.3%)...Conclusively, PoEE exerted potent anticancer effects through multi-target modulation of the PI3K/Akt/mTOR signaling axis. These underscore PoEE's promise as a low-toxicity natural therapeutic or adjuvant for hormone receptor-positive and pathway-driven breast cancers.

Following a multidisciplinary tumor board discussion, the patient underwent reduced-intensity induction with mini-CVD (cyclophosphamide, vincristine, and dexamethasone) combined with dasatinib and central nervous system prophylaxis. The patient experienced clinical and hematologic improvement and was discharged on continuous tyrosine kinase inhibitor therapy with close monitoring. This case highlights the diagnostic workup, multidisciplinary treatment planning, and early therapeutic response in an elderly patient with Ph+ B-ALL while comparing these findings with the current literature.

P2, N=62, West China Hospital of Sichuan University; West China Hospital of Sichuan University

He responded poorly to cytotoxic drugs, but achieved a durable complete remission with three cycles of oral prednisolone...However, he achieved complete remission with a combination of oral methotrexate and vincristine...There is no universal standard guideline for managing Rosai-Dorfman disease. However, patients with symptomatic disease, those experiencing emergency symptoms, and cases of relapse will require medical or surgical intervention to improve their outcomes.

This exploratory analysis characterizes transcriptional differences among response groups and identifies candidate genes and pathways that may contribute to vincristine sensitivity or resistance in CTVT. Considering the small number of resistant tumors included, these results are preliminary and require validation in larger, independent cohorts.

In silico drug sensitivity analysis further suggested that high-risk patients may develop poorer sensitivity to five clinical drugs, including Cisplatin, Oxaliplatin, and Vinorelbine. The six-m7G-related-lncRNA signature represents a promising prognostic tool for EGC that may facilitate personalized risk stratification and guide clinical decision-making regarding adjuvant or immunotherapeutic strategies.

These findings indicate that vinorelbine-based regimens inhibit tumor spheroid growth predominantly through cytostatic mechanisms rather than induction of apoptosis. This non-apoptotic growth-control strategy may be relevant for the management of apoptosis-resistant endometrial cancer.

It was demonstrated that the IONPs primarily bound to the membrane of Jurkat cells and formed ordered assembly structures under MF, which disrupted cellular homeostasis by activating the calcium-NFAT-FasL signaling pathway, hyperpolarizing mitochondria, reprogramming metabolism, and disrupting cytoskeletal assembly. In conclusion, the MAMS strategy sensitized Jurkat cells to VCR by multilevel interference with the homeostasis of cells, providing a promising approach for developing more effective and less cytotoxic T-ALL treatment regimens.