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    DRUG:

    topsalysin (PRX302)

    i
    Other names: PRX-302, PSA-PA 1, PSA-PAH 1, PORxin, PRX302
    Associations

    News

    Trials
    Company:
    Sophiris Bio
    Drug class:
    Apoptosis stimulant, Cell modulator, KLKB1 inhibitor
    Related drugs:
    Associations

    News

    Trials
    over4years
    Microparticle Encapsulation of a Prostate-Targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-Resistant Prostate Cancer. (PubMed, Mol Cancer Ther)
    Microparticle encapsulation prevented PRX302 from immediately interacting with GPI-anchored proteins as demonstrated in a competition assay, which resulted in an increased therapeutic index and significant anti-tumor efficacy following a single dose of PRX302-loaded microparticles in a preclinical model of prostate cancer liver metastasis with no obvious toxicity. These results document PRX302 released from PLGA microparticles demonstrate in vivo anti-tumor efficacy in a clinically-relevant preclinical model of metastatic prostate cancer.
    Preclinical • Journal
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    KLK3 (Kallikrein-related peptidase 3)
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    topsalysin (PRX302)