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DRUG:

topsalysin (PRX302)

i
Other names: PRX-302, PSA-PA 1, PSA-PAH 1, PORxin, PRX302
Associations
Trials
Company:
Sophiris Bio
Drug class:
Apoptosis stimulant, Cell modulator, KLKB1 inhibitor
Associations
Trials
4years
Microparticle Encapsulation of a Prostate-Targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-Resistant Prostate Cancer. (PubMed, Mol Cancer Ther)
Microparticle encapsulation prevented PRX302 from immediately interacting with GPI-anchored proteins as demonstrated in a competition assay, which resulted in an increased therapeutic index and significant anti-tumor efficacy following a single dose of PRX302-loaded microparticles in a preclinical model of prostate cancer liver metastasis with no obvious toxicity. These results document PRX302 released from PLGA microparticles demonstrate in vivo anti-tumor efficacy in a clinically-relevant preclinical model of metastatic prostate cancer.
Preclinical • Journal
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KLK3 (Kallikrein-related peptidase 3)
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topsalysin (PRX302)