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    BIOMARKER:

    TOP2A amplification

    i
    Other names: TOP2A, DNA Topoisomerase II Alpha, Topoisomerase (DNA) II Alpha 170kDa, DNA Topoisomerase II, Alpha Isozyme, DNA Topoisomerase 2-Alpha, TOP2, DNA Topoisomerase II, 170 KD
    Entrez ID:
    7153
    Related biomarkers:
    Expression
    CNA
    Related tests:
    19d
    Elucidating the prognostic and therapeutic significance of TOP2A in various malignancies. (PubMed, Cancer Genet)
    The increased expression of TOP2A is associated with poor clinical outcomes, indicating its potential as a valuable biomarker for assessing risk and stratifying treatment in these malignancies. However, further investigation is needed to elucidate the underlying mechanisms by which TOP2A influences cancer progression and to explore its potential as a therapeutic target.
    Review • Journal
    |
    TOP2A (DNA topoisomerase 2-alpha)
    |
    TOP2A amplification • TOP2A expression
    8ms
    Neoadjuvant anthracycline-based (5-FEC) or anthracycline-free (docetaxel/carboplatin) chemotherapy plus trastuzumab and pertuzmab in HER2 + BC patients according to their TOP2A: a multicentre, open-label, non-randomized phase II trial. (PubMed, Breast Cancer Res Treat)
    Our results showed high pCR rates with Trastuzumab and Pertuzumab associated to chemotherapy. They were similar in TOP2A + and TOP2A- groups and the current role of neoadjuvant anthracycline-based chemotherapy remains questioned.
    P2 data • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • TOP2A (DNA topoisomerase 2-alpha)
    |
    HER-2 amplification • TOP2A amplification
    |
    Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab)
    over2years
    Oral Etoposide and Trastuzumab Use for HER2-Positive Metastatic Breast Cancer: A Retrospective Study from the Institut Curie Hospitals. (PubMed, Cancers (Basel))
    Our analysis suggests a favorable efficacy and toxicity profile for VP16-T in patients with heavily pretreated HER2+ MBC.
    Retrospective data • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • TOP2A (DNA topoisomerase 2-alpha)
    |
    HER-2 positive • HER-2 amplification • TOP2A amplification
    |
    Herceptin (trastuzumab) • etoposide oral
    over4years
    FISH Analysis of TOP2A and HER-2 Aberrations in Female Breast Carcinoma on Archived Material: Egyptian NCI Experience. (PubMed, Appl Immunohistochem Mol Morphol)
    HER-2 and TOP2A genes amplification are 2 separate genetic yet closely related events in breast cancer. Polysomy of chromosome 17 is proposed to be an early event in occurrence of TOP2A gene amplification. Further studies regarding effect of TOP2A gene in response to anthracyclines in Egyptian population should be planned for to establish its role in therapeutic planning.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • TOP2A (DNA topoisomerase 2-alpha)
    |
    TOP2A amplification