Checkpoint inhibition • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker • Checkpoint block
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PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2)
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PIK3CA mutation • PTEN mutation • TMB-L
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FoundationOne® CDx
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Tecentriq (atezolizumab) • tiragolumab (RG6058)