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BIOMARKER:

TLR8 expression

i
Other names: TLR8, Toll Like Receptor 8, CD288, CD288 Antigen
Entrez ID:
Related biomarkers:
3ms
Subgroup Analysis of TLR2, -3, -4 and -8 in Relation to the Severity of Clinical Manifestations of Cervical HPV Infection. (PubMed, Int J Mol Sci)
TLRs' mRNA expression was analyzed using real-time reverse transcription polymerase chain reaction (RT-PCR). Our results indicate the potential significance of TLR3, TLR4 and TLR8 in responding to HPV infection and its progression to SILs and CC, highlighting the importance of HPV polyinfection in relation to TLR4 and TLR8.
Journal
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TLR4 (Toll Like Receptor 4) • TLR8 (Toll Like Receptor 8) • TLR3 (Toll Like Receptor 3) • TLR2 (Toll Like Receptor 2)
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TLR8 expression
7ms
METTL5 promotes cell proliferation, invasion, and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer. (PubMed, World J Gastrointest Oncol)
The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis, thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.
Journal • IO biomarker
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TLR8 (Toll Like Receptor 8)
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TLR8 expression
8ms
Expression of Toll-like receptors in oral squamous cell carcinoma. (PubMed, PLoS One)
Significant increase in TRL4 was seen in BM zone of sample colonized with Candida (P = 0.01). According to the limited number of samples, our data indicates downregulation of TLRs and NF-κB in OSCC, and upregulation of TLR4 expression with presence of Candida.
Journal • IO biomarker
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NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • TLR4 (Toll Like Receptor 4) • TLR8 (Toll Like Receptor 8) • TLR7 (Toll Like Receptor 7)
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TLR8 expression
10ms
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement. (PubMed, J Autoimmun)
This work represents a proof of concept that the pool of extracellular miRNAs overexpressed in RA joints can act as a physiological activator of inflammation via the stimulation of TLR8 expressed by human DCs, which in turn exert arthritogenic functions. In this scenario, pharmacological inhibition of TLR8 might offer a new therapeutic option to reduce inflammation and osteoclast-mediated bone destruction in RA.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • TLR8 (Toll Like Receptor 8) • TLR7 (Toll Like Receptor 7)
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TLR8 expression
1year
Intracellular Toll-Like Receptors Modulate Adaptive Immune Responses in Head and Neck Cancer. (PubMed, Viral Immunol)
In conclusion, the role of HPV in OC and OPC is minor, and p16 constitutes a poor biomarker for HPV positivity in Kerala, India. Intracellular TLRs are correlated with the degree of inflammation in OPC but not in OC and may potentially constitute a medical target in the therapy of HNC in the future.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • TLR9 (Toll Like Receptor 9) • TLR8 (Toll Like Receptor 8) • TLR3 (Toll Like Receptor 3) • TLR7 (Toll Like Receptor 7)
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TLR9 expression • TLR8 expression