^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TLR8 expression

    i
    Other names: TLR8, Toll Like Receptor 8, CD288, CD288 Antigen
    Entrez ID:
    51311
    Related biomarkers:
    Expression
    1m
    Expression of Toll-like receptors in oral squamous cell carcinoma. (PubMed, PLoS One)
    Significant increase in TRL4 was seen in BM zone of sample colonized with Candida (P = 0.01). According to the limited number of samples, our data indicates downregulation of TLRs and NF-κB in OSCC, and upregulation of TLR4 expression with presence of Candida.
    Journal • IO biomarker
    |
    NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • TLR4 (Toll Like Receptor 4) • TLR8 (Toll Like Receptor 8) • TLR7 (Toll Like Receptor 7)
    |
    TLR8 expression
    3ms
    Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement. (PubMed, J Autoimmun)
    This work represents a proof of concept that the pool of extracellular miRNAs overexpressed in RA joints can act as a physiological activator of inflammation via the stimulation of TLR8 expressed by human DCs, which in turn exert arthritogenic functions. In this scenario, pharmacological inhibition of TLR8 might offer a new therapeutic option to reduce inflammation and osteoclast-mediated bone destruction in RA.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TLR8 (Toll Like Receptor 8) • TLR7 (Toll Like Receptor 7)
    |
    TLR8 expression
    5ms
    Intracellular Toll-Like Receptors Modulate Adaptive Immune Responses in Head and Neck Cancer. (PubMed, Viral Immunol)
    In conclusion, the role of HPV in OC and OPC is minor, and p16 constitutes a poor biomarker for HPV positivity in Kerala, India. Intracellular TLRs are correlated with the degree of inflammation in OPC but not in OC and may potentially constitute a medical target in the therapy of HNC in the future.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • TLR9 (Toll Like Receptor 9) • TLR8 (Toll Like Receptor 8) • TLR3 (Toll Like Receptor 3) • TLR7 (Toll Like Receptor 7)
    |
    TLR9 expression • TLR8 expression