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    BIOMARKER:

    TGFB1 elevation

    i
    Other names: TGFB1I1, Transforming growth factor beta 1 induced transcript 1, Androgen receptor-associated protein of 55 KDa, Hydrogen peroxide-inducible clone 5 protein, ARA55, TSC-5, HIC-5
    Entrez ID:
    7041
    3ms
    Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling. (PubMed, Exp Mol Med)
    Cat D deletion inhibits M2-like TAM polarization through TGFBI-mediated CCL20 expression, reprogramming the immunosuppressive TME. Our results open a potential new avenue for therapy focused on eliminating tumor metastasis.
    Journal
    |
    CCL20 (C-C Motif Chemokine Ligand 20) • CTSD (Cathepsin D) • TGFBI (Transforming Growth Factor Beta Induced)
    |
    TGFB1 elevation