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DRUG:

IPH6501

i
Other names: IPH6501, NKCE4, tetra-specific ANKET molecule, IPH65
Company:
Innate
Drug class:
CD20 inhibitor, NK cell stimulant
Related drugs:
7d
A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma. (PubMed, Sci Immunol)
We evaluated IPH6501, a clinical-stage, tetraspecific NK cell engager (NKCE) armed with a non-alpha IL-2 variant (IL-2v), which targets CD20 and was developed for treating B cell non-Hodgkin lymphoma (B-NHL)...In vivo studies in nonhuman primates and tumor mouse models further validated its efficacy and revealed that CD20-NKCE-IL2v induces peripheral NK cell homing at the tumor site. CD20-NKCE-IL2v emerges as a potential alternative in the treatment landscape of B-NHL.
Journal
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IL2 (Interleukin 2)
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CD20 negative
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IPH6501
9ms
Phase1/2 Study of IPH6501 in Patients With Relapsed /Refractory B-Cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1/2, N=184, Recruiting, Innate Pharma | Not yet recruiting --> Recruiting | Initiation date: Oct 2023 --> Mar 2024
Enrollment open • Trial initiation date
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IPH6501
over1year
IPH6501 IS A FIRST-IN-CLASS TETRASPECIFIC ANTIBODY-BASED NATURAL KILLER CELL ENGAGER THERAPEUTIC DEVELOPED FOR THE TREATMENT OF B-CELL NON-HODGKIN'S LYMPHOMAS (EHA 2023)
Despite several generations of CD20-targeting drugs including rituximab, ofatumumab, and obinutuzumab, and more recent approvals of new CD20-targeting agents, innovative strategies are still needed for B-NHL patients who relapse or are refractory (R/R) after multiple lines of treatment. Our preclinical data showed that IPH6501, a CD20-targeting tetraspecific antibody-based NK cell engager therapeutic, could be a powerful first-in-class new asset to harness the anti-tumor functions of NK cells in CD20 +B-cell malignancies. IPH6501 is expected to enter FIH clinical study in 2023. 1.
IO biomarker
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IL2RA (Interleukin 2 receptor, alpha) • FCGR3A (Fc Fragment Of IgG Receptor IIIa)
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CD19 positive • CD20 expression • IL2RA expression
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Rituxan (rituximab) • Gazyva (obinutuzumab) • IPH6501