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    DRUG:

    STA551

    i
    Other names: STA551, Switch antibody molecule, STA 551, STA-551
    Associations

    News

    Trials
    Company:
    Roche
    Drug class:
    CD137 agonist
    Related drugs:
    Associations

    News

    Trials
    over2years
    Single cell RNA sequencing revealed that the mechanism of the synergistic efficacy of STA551 and immune checkpoint inhibitor results from the induction of highly activated T cells in tumor (AACR 2022)
    The combination of STA551 and PD-L1 showed synergistic anti-tumor efficacy in a colon38-bearing human CD137 knock-in mouse model. Detailed mechanistic analysis showed that the combination of STA551 and PD-L1 induced highly activated CD8+T cells expressing chemokines and cytokines compared to monotherapy. This cluster also express chemokines, suggesting that other immune cells have been recruited.
    Clinical • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8)
    |
    PD-L1 expression
    |
    STA551