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    BIOMARKER:

    SMAD4 positive

    i
    Other names: HSMAD4, Mothers Against DPP Homolog 4, SMAD, Mothers Against DPP Homolog 4, Deleted In Pancreatic Carcinoma Locus 4, SMAD, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic, Drosophila, Homolog Of, 4, MADH4, MAD, Mothers Against Decapentaplegic Homolog 4, Mothers Against Decapentaplegic Homolog 4, MAD Homolog 4, SMAD4, SMAD Family Member 4, Deletion Target In Pancreatic Carcinoma 4
    Entrez ID:
    4089
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    7ms
    Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling. (PubMed, Cell Commun Signal)
    BMP4 expression is required for suppression of metastasis regardless of the SMAD4 status of the tumor cells. Since BMP4 is a secreted protein, we conclude that it can act both in an autocrine manner in SMAD4-expressing tumor cells and in a paracrine manner on stromal cells to suppress metastasis. Deletion of SMAD4 from tumor cells does not prevent BMP4 from suppressing metastasis via a paracrine mechanism.
    Journal
    |
    SMAD4 (SMAD family member 4) • MYO1F (Myosin IF) • BMP4 (Bone Morphogenetic Protein 4)
    |
    SMAD4 deletion • SMAD4 expression • SMAD4 positive
    12ms
    SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer. (PubMed, Acta Pharmacol Sin)
    Moreover, SMAD4 enhanced the cytotoxic effect of gemcitabine combined with RSL3 in highly invasive PDAC cells. This study provides new ideas for the treatment of PDAC, especially SMAD4-positive PDAC.
    Journal • Tumor cell
    |
    SMAD4 (SMAD family member 4) • GPX4 (Glutathione Peroxidase 4) • TGFB1 (Transforming Growth Factor Beta 1)
    |
    SMAD4 positive
    |
    gemcitabine • RSL3