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DRUG:

SHR-8068

i
Other names: SHR-8068, SHR8068, SHR 8068
Associations
Company:
Jiangsu Hengrui Pharma
Drug class:
CTLA4 inhibitor
Associations
1d
Enrollment open
|
Avastin (bevacizumab) • Tyvyt (sintilimab) • Ariely (adebrelimab) • SHR-8068
2d
Enrollment open
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SHR-A2102 • Ariely (adebrelimab) • SHR-8068
21d
SHR-8068 combined with adebrelimab and bevacizumab in the treatment of refractory advanced colorectal cancer: study protocol for a single-arm, phase Ib/II study. (PubMed, Front Immunol)
This proof-of-concept study would provide safety and efficacy signals of this novel combination treatment for the MSS CRCs in the late-line setting. And it may offer new insights on the clinical application of dual immunotherapy combined with anti-angiogenic therapy in the MSS CRC.
Clinical protocol • P1/2 data • Journal • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Metastases
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MSI (Microsatellite instability)
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Avastin (bevacizumab) • Airuituo (bevacizumab biosimilar) • Ariely (adebrelimab) • SHR-8068
30d
A Trial of SHR-A2102 With Antitumor Therapy in Advanced Urothelial Carcinoma (clinicaltrials.gov)
P1/2, N=90, Not yet recruiting, Shanghai Hengrui Pharmaceutical Co., Ltd.
New P1/2 trial • Combination therapy • Metastases
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SHR-A2102 • Ariely (adebrelimab) • SHR-8068
1m
New P3 trial
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Avastin (bevacizumab) • Tyvyt (sintilimab) • Ariely (adebrelimab) • SHR-8068
2ms
New P1/2 trial • Combination therapy • Metastases
|
SHR-A2102 • Ariely (adebrelimab) • SHR-8068
3ms
Study of SHR-8068 Combined With Adebrelimab and Platinum-containing Chemotherapy in the Treatment of Advanced Gastric and Esophageal Cancer (clinicaltrials.gov)
P2, N=240, Recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | N=120 --> 240 | Trial completion date: Aug 2025 --> Dec 2025 | Trial primary completion date: Feb 2025 --> Jun 2025
Enrollment change • Trial completion date • Trial primary completion date • Metastases
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cisplatin • paclitaxel • capecitabine • oxaliplatin • Ariely (adebrelimab) • SHR-8068
4ms
Enrollment open • Combination therapy • Metastases
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cisplatin • gemcitabine • Ariely (adebrelimab) • SHR-8068
5ms
Study of SHR-8068 Combined With Adebrelimab and Bevacizumab in the Treatment of Advanced Hepatocellular Carcinoma (clinicaltrials.gov)
P1/2, N=129, Recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open • Metastases
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Avastin (bevacizumab) • Ariely (adebrelimab) • SHR-8068
5ms
New P2 trial • Combination therapy • Metastases
|
cisplatin • gemcitabine • Ariely (adebrelimab) • SHR-8068
6ms
New P1/2 trial • Combination therapy • Metastases
|
carboplatin • Ariely (adebrelimab) • SHR-8068 • SHR-A1921
7ms
New P1/2 trial • Metastases
|
Avastin (bevacizumab) • Ariely (adebrelimab) • SHR-8068
8ms
Enrollment open
|
cisplatin • paclitaxel • capecitabine • oxaliplatin • Ariely (adebrelimab) • SHR-8068
9ms
New P2 trial • Metastases
|
cisplatin • paclitaxel • capecitabine • oxaliplatin • Ariely (adebrelimab) • SHR-8068
2years
Phase Ib/II Study of SHR-8068 Injection in the Treatment of Advanced Non-small Cell Lung Cancer (clinicaltrials.gov)
P1/2, N=168, Recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open
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PD-L1 (Programmed death ligand 1)
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cisplatin • carboplatin • paclitaxel • Ariely (adebrelimab) • SHR-8068
over2years
Phase Ib/II Study of SHR-8068 Injection in the Treatment of Advanced Non-small Cell Lung Cancer (clinicaltrials.gov)
P1/2, N=168, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.
New P1/2 trial
|
PD-L1 (Programmed death ligand 1)
|
cisplatin • carboplatin • paclitaxel • Ariely (adebrelimab) • SHR-8068