selenomethionine (SLM)

Compared with the sodium selenite (SeS), nano-selenium (SeN), selenomethionine (SeM), and selenium-enriched yeasts (SeY), as novel selenium sources, are increasingly popular in laying hen production...Meanwhile, the gut microbiota and differential metabolites of ovary were closely related to laying performance and antioxidant capacity of ovary. Therefore, 0.4 mg/kg SeN, SeM, and SeY showed an advantage on improving laying rate, ovary function, and gut microbiota in laying hens, and they could be potential additives using in laying hen production.

Selenomethionine (SeMet), a natural amino acid with antioxidant and anticancer properties, was investigated for its protective effects against ZEA-induced nephrotoxicity...Notably, 0.35 mg/kg SeMet demonstrated optimal renal protection. These findings highlight SeMet's potential as a dietary supplement to mitigate ZEA-induced kidney injury via modulation of autophagy and apoptosis pathways.

By reversing the above changes induced by OTA, SeMet alleviated OTA-induced renal injury and inhibited OTA-induced lipid peroxidation and ferroptosis. These findings indicate that SeMet alleviates OTA-induced renal injury by inhibiting ferroptosis, suggesting that SeMet can be used as a feed additive in mycotoxin-contaminated environments.

In the present work, a single cell ICP-MS (scICP-MS) methodology was optimised to evaluate the cellular uptake of cisplatin in the presence of three potential nephroprotectors such as chitosan-stabilised selenium nanoparticles (Ch-SeNPs), selenomethionine (SeMet) and methionine (Met). Results were compared by two different scICP-MS settings (a conventional introduction system and a special configuration for intact cells), as well as with the classical digestion-based bulk analysis. Our results demonstrate the potential of scICP-MS for metallomic cellular studies to improve cisplatin-based therapies.

Neither suboptimal nor adequate concentrations of either selenium species affected malignant cell transformation even though selenoprotein expression was modulated. Overall, the current data suggest that high concentrations of selenium have different effects on malignant cell transformation depending on the distinct selenium species applied.

Additionally, SeMet enhanced the activity of antioxidant enzymes (T-SOD and GSH-PX) and reduced the levels of proinflammatory cytokines (IL-6 and TNF-α) without hepatorenal toxicity. These findings establish SeMet as a multifaceted therapeutic candidate for lung cancer through dual induction of apoptosis-ferroptosis and angiogenesis inhibition.

SeMet pretreatment significantly decreased the degree of intestinal epithelial cell apoptosis. Therefore, we showed that SeMet can reduce inflammation and enhance intestinal barrier function to improve the production performance of rabbits infected with KP.

In this study, we demonstrated that L-selenomethionine (L-SeMet), a gut microbial metabolite, acts as a positive regulator of immunotherapy...Mechanistically, L-SeMet enhances T cell receptor (TCR) signaling by promoting LCK phosphorylation. Collectively, our findings reveal that the gut microbial metabolite L-SeMet inhibits colorectal tumor growth by potentiating CD8+ T cell functions, providing a potential therapeutic strategy for colorectal cancer treatment.

SLM (4000 μg) in sequential combination with axitinib is well tolerated with encouraging efficacy.

P1, N=56, Completed, University of Auckland, New Zealand | Active, not recruiting --> Completed

Seleno-L-methionine (SLM) treatment in a nude mouse xenograft model showed a significant tumor growth inhibition and TGF-β1 downregulation at non-toxic doses. These findings suggest that selenium-mediated downregulation of TGF-β1, PD-L1, and VEGF could be a viable therapeutic strategy for ccRCC.

Furthermore, Se-Met alleviated heat-induced activation of p-p38MAPK/p38MAPK (HE-C vs. HE-S: 1.79-fold, p < 0.05) and p-HSPB1/HSPB1 (HE-C vs. HE-S: 2.72-fold, p < 0.05). In conclusion, p38MAPK/HSPB1 might be involved in Se-Met-mediated alleviation of heat-induced cell apoptosis, cell viability and testosterone secretion impairments in sheep LCs.