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DRUG:

Welireg (belzutifan)

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Company:

Merck (MSD)

Drug class:

HIF-2α inhibitor

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No biomarker	Renal Cell Carcinoma	No biomarker	Renal Cell Carcinoma	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	Neuroendocrine Tumor	VHL mutation	Neuroendocrine Tumor	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	CNS Tumor	VHL mutation	CNS Tumor	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	Renal Cell Carcinoma	VHL mutation	Renal Cell Carcinoma	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
No biomarker	Kidney Cancer	No biomarker	Kidney Cancer	belzutifan Sensitive: A2 - Guideline belzutifan Sensitive : A2	belzutifan Sensitive: A2 - Guideline belzutifan Sensitive : A2
VHL mutation	Clear Cell Renal Cell Carcinoma	VHL mutation	Clear Cell Renal Cell Carcinoma	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1
VHL mutation	Glioblastoma	VHL mutation	Glioblastoma	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1
EPAS1 G323E	Clear Cell Renal Cell Carcinoma	EPAS1 G323E	Clear Cell Renal Cell Carcinoma	belzutifan Sensitive: D – Preclinical belzutifan Sensitive : D	belzutifan Sensitive: D – Preclinical belzutifan Sensitive : D
EPAS1 S304M	Clear Cell Renal Cell Carcinoma	EPAS1 S304M	Clear Cell Renal Cell Carcinoma	belzutifan Sensitive: D – Preclinical belzutifan Sensitive : D	belzutifan Sensitive: D – Preclinical belzutifan Sensitive : D