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    almost4years
    [VIRTUAL] SCR6106, an oral and brain penetrant SERD demonstrated anti-tumor activities in vitro and in vivo (AACR 2021)
    Fulvestrant, a selective estrogen receptor degrader (SERD) is approved to treat HR+ metastatic breast cancer in patients with disease progression after endocrine therapy. In conclusion, SCR6106 is a novel, potent and oral SERD, which demonstrated anti-tumor activities in vitro and in vivo. It showed high potential ability to cross the blood-brain barrier, and could be used to treat HR+ patients with brain metastasis.
    Preclinical
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    ER (Estrogen receptor)
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    HR positive
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    fulvestrant • SCR6106