^
    3ms
    HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy. (PubMed, J Biol Chem)
    Deletion of HSP90α or HSP90β by CRISPR-Cas9 or inhibition of HSP90 activity by IPI-504 down-regulates RDH5 protein level, but not its mRNA expression, and this downregulation is restored by autophagic inhibitors (3-MA, CQ and Baf-A1) and siRNA of ATG5 or ATG7, but not by the proteasome inhibitor MG132. RDH5 is a novel client candidate of HSP90. The downregulation of RDH5 may be responsible for the nyctalopia side effect noted in cancer patients receiving HSP90 inhibitor treatment currently in the clinical trial.
    Journal
    |
    SQSTM1 (Sequestosome 1) • ATG5 (Autophagy Related 5) • ATG7 (Autophagy Related 7) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    |
    retaspimycin (IPI-504) • MG132
    2years
    Exploring breast cancer exosomes for novel biomarkers of potential diagnostic and prognostic importance. (PubMed, 3 Biotech)
    Additionally, this in silico analysis found that the anticancer agents and HSP90 inhibitors such as ganetespib, retaspimycin, and tanespimycin would have considerable potential in the treatment of BC. However, these findings need to be further confirmed by laboratory and clinical studies for validating their potential applications. The online version contains supplementary material available at 10.1007/s13205-022-03422-w.
    Journal
    |
    ENO1 (Enolase 1)
    |
    tanespimycin (BMS-722782) • ganetespib (ADX-1612) • retaspimycin (IPI-504)