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    BIOMARKER:

    RAD21 mutation

    i
    Other names: RAD21, RAD21 Cohesin Complex Component, HHR21, SCC1, Double-Strand-Break Repair Protein Rad21 Homolog, Sister Chromatid Cohesion 1, Nuclear Matrix Protein 1, SCC1 Homolog, Kleisin, NXP1, Protein Involved In DNA Double-Strand Break Repair, RAD21 (S. Pombe) Homolog, RAD21 Homolog (S. Pombe), RAD21 Homolog, HRAD21, CDLS4, RAD21, MCD1
    Entrez ID:
    5885
    Related biomarkers:
    CNA
    Others
    1m
    Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. (PubMed, Am J Physiol Cell Physiol)
    Granulocytes from rad21+/- showed upregulation of stress hematopoiesis factor, cebpb. These findings show that normal rad21 is required to maintain steady erythropoiesis and granulopoiesis in the adult zebrafish marrow.
    Journal
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    RAD21 (RAD21 Cohesin Complex Component)
    |
    RAD21 mutation
    9ms
    RAD21 mutations in acute myeloid leukemia. (PubMed, Leuk Lymphoma)
    This study showed that RAD21-mutated AML often associates with monocytic differentiation, CD7 expression, co-existing mutations in epigenetic regulators, a normal karyotype, and poor prognosis. Our findings provide additional insights into the morphologic, immunophenotypic, and genomic profile of RAD21 mutation-positive AML and suggest that RAD21 mutations should be evaluated for independent prognostic significance in AML.
    Journal
    |
    STAG2 (Stromal Antigen 2) • RAD21 (RAD21 Cohesin Complex Component) • CD7 (CD7 Molecule)
    |
    STAG2 mutation • RAD21 mutation • CD7 expression