Pituitary Gland Carcinoma

Compared to temozolomide (TMZ), PLB more potently inhibited the viability of PDFS cells...The mechanism involves suppression of the Nrf2/FTH1 pathway, subsequent upregulation of NCOA4, and ferritinophagy-driven iron overload. These results identify PLB as a potential ferroptosis inducer and warrant further investigation into its therapeutic potential for NFPA.

These findings may contribute to understanding the genetic landscape of acromegaly, and the gene identified may be of interest for further research on gene regulation of invasiveness and proliferation in somatotropinomas.

Our findings indicate that LAHS is characterized by a pronounced Warburg-like metabolic state, primarily involving glycolytic monocytes. Hyperlactataemia is associated with adverse outcomes and may guide the development of novel therapeutic strategies targeting immunometabolic pathways.

These findings support that GH responsiveness to CRH identifies a biologically distinct subset of somatotroph adenomas characterized by corticotroph-like features, larger tumor size, and reduced GH secretory capacity. GH responsiveness to CRH may serve as a noninvasive indicator of intrinsic tumor biology and behavior.

Pituitary metastasis frequently presents with combined endocrine dysfunction and neuro-ophthalmologic compromise, occasionally as an acute sellar emergency. In oncologic patients with sellar lesions, the combination of AVP-D, visual deterioration, and non-prolactinoma-range hyperprolactinemia should raise suspicion for pituitary metastasis and prompt urgent endocrine and local evaluation.

Endoscopic transsphenoidal surgery for NFPAs is associated with transient increases in circulating brain injury biomarkers, particularly in patients with hypothalamic compression. Our findings revealed that these elevations were not related to long-term fatigue or cognitive decline, suggesting that they may reflect short-term surgical effects without sustained functional consequences.

P=N/A, N=20, Recruiting, West China Hospital | Not yet recruiting --> Recruiting

Despite control of the primary and hepatic lesions, ovarian metastasis developed, which was associated with reduced CD4+ TILs. The presence of CD4+ and CD8+ TILs may underlie the immunological foundation for PD-1 blockade efficacy in pituitary carcinoma, supported by the detection of tumor-resident TCR clonotypes in peripheral blood during a positive therapeutic response.

CCND1, POU5F1, SOX2, HNF1A, BRCA1, and FOXA1 were identified as key molecules that may serve as potential biomarkers for diagnosis and targeted therapy of NFPA.

Once-daily oral paltusotine treatment was well tolerated and resulted in long-term disease control, including biochemical, symptom, and pituitary tumor stability, for up to 4 years.

Raised serum prolactin has not been previously associated with Schöpf-Schulz-Passarge syndrome. The significance of raised serum prolactin in the context of multiple eyelid hidrocystomas is discussed.

In vivo, the virus suppressed tumor growth and lessened systemic tumor effects; when delivered via the hydrogel into surgical cavities, it completely eliminated residual tumors without detectable toxicity in major organs. This targeted, localized strategy, thus has translational potential as an adjuvant therapy for reducing the recurrence of Cushing's disease.