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    BIOMARKER:

    PIK3R1 overexpression

    i
    Other names: PIK3R1, Phosphoinositide-3-Kinase Regulatory Subunit 1, Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha, Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha, Phosphoinositide-3-Kinase Regulatory Subunit Alpha, PtdIns-3-Kinase Regulatory Subunit Alpha, PI3K Regulatory Subunit Alpha, PI3-Kinase Subunit P85-Alpha, GRB1, Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha), Phosphatidylinositol 3-Kinase
    Entrez ID:
    5295
    Related biomarkers:
    Mutation
    Others
    over2years
    miR-455-5p enhances 5-fluorouracil sensitivity in colorectal cancer cells by targeting PIK3R1 and DEPDC1. (PubMed, Open Med (Wars))
    In conclusion, miR-455-5p enhanced 5-Fu sensitivity by targeting PIK3R1 and DEPDC1 in CRC. This study provides a novel role of miR-455-5p in CRC and restoring miR-455-5p might be a therapeutic strategy to enhance chemosensitivity to 5-Fu.
    Journal
    |
    PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR455 (MicroRNA 455)
    |
    PIK3R1 overexpression
    |
    5-fluorouracil
    over3years
    miR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1. (PubMed, J Clin Lab Anal)
    miR-92a is up-regulated in cervical cancer tissues. miR-92a promotes the malignant development of cervical cancer by negatively regulating PIK3R1.
    Journal
    |
    PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)
    |
    PIK3R1 overexpression