PIK3R1 overexpression

News alerts, weekly reports and conference planners

Entrez ID:

5295

Related biomarkers:

Mutation

Others

2ms

miR-21-5p Targets PIK3R1 to Regulate the NF-κB Signaling Pathway, Inhibiting the Invasion and Progression of Prolactinoma. (PubMed, Int J Endocrinol)

Subsequent in vitro experiments demonstrated that overexpression of PIK3R1 significantly attenuated the biological effects of miR-21-5p in PRL cells, such as promoting proliferation and invasion. Finally, we explored the mechanism by which PIK3R1 affects PRL progression and found that the inhibition of IκBa degradation by PIK3R1 impacts PRL progression via the miR-21-5p/PIK3R1/MMP pathway.

2 months ago

Journal

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR21 (MicroRNA 21)

PIK3R1 overexpression

2ms

Immune checkpoint expression and therapeutic implications in IDH1-mutant and wild-type glioblastomas. (PubMed, Curr Probl Cancer)

Our findings indicate that PDCD1 and CD274 are highly expressed irrespective of IDH1 mutation statuses, suggesting that glioblastomas could benefit from immunotherapy. Moreover, IDH1Mu glioblastomas may require a combination of PI3K/AKT/mTOR inhibitors and immunotherapy due to PIK3R1 overexpression.

2 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • PTEN (Phosphatase and tensin homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • PD-1 (Programmed cell death 1) • MUC16 (Mucin 16, Cell Surface Associated) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • ITGB2 (Integrin Subunit Beta 2)

IDH1 mutation • PIK3R1 overexpression

2ms

Correlation Between PIK3R1 Expression and Cell Growth in Human Breast Cancer Cell Line BT-474 and Clinical Outcomes. (PubMed, World J Oncol)

We concluded that downregulated PIK3R1 in BT-474 cells resulted in an increased cell growth and upregulated AKT-mTOR signaling. Clinically, the high-expressed PIK3R1 protein in tumors correlates positively with patients' outcome in stage I and II breast cancer.

2 months ago

Clinical data • Preclinical • Journal

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)

PIK3CA mutation • PIK3R1 overexpression

3ms

miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis. (PubMed, Am J Cancer Res)

Overexpression of hsa_circ_0087104 suppressed in vitro migration and invasion of ESCC cells and this suppressive effect could be weakened by upregulation of miR-542-3p. Collectively, the current findings elucidated a potential hsa_circ_0087104/miR-542-3p/PIK3R1 axis that might be involved in suppression of lymph node metastasis of ESCC.

3 months ago

Journal

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR532 (MicroRNA 532) • MIR542 (MicroRNA 542)

PIK3R1 overexpression

almost3years

miR-455-5p enhances 5-fluorouracil sensitivity in colorectal cancer cells by targeting PIK3R1 and DEPDC1. (PubMed, Open Med (Wars))

In conclusion, miR-455-5p enhanced 5-Fu sensitivity by targeting PIK3R1 and DEPDC1 in CRC. This study provides a novel role of miR-455-5p in CRC and restoring miR-455-5p might be a therapeutic strategy to enhance chemosensitivity to 5-Fu.

almost 3 years ago

Journal

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR455 (MicroRNA 455)

PIK3R1 overexpression

5-fluorouracil

almost4years

miR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1. (PubMed, J Clin Lab Anal)

miR-92a is up-regulated in cervical cancer tissues. miR-92a promotes the malignant development of cervical cancer by negatively regulating PIK3R1.

almost 4 years ago

Journal

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)

PIK3R1 overexpression