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    BIOMARKER:

    PIK3CA exon 20 mutation + HR positive

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K, ESR1, Era, ESR, NR3A1, ER, ER beta, PGR, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3, NR3C3
    Entrez ID:
    2099; 5290; 5241
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over3years
    Multi-Site Tumour Sampling Improves the Detection of Intra-Tumour Heterogeneity in Oral and Oropharyngeal Squamous Cell Carcinoma. (PubMed, Front Med (Lausanne))
    MSTS was more representative than RP. Therefore, MSTS can compensate the RP limitations in ITH detection especially in large tumours.
    Journal
    |
    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1)
    |
    TP53 mutation • PIK3CA mutation • PIK3CA H1047R • CCND1 expression • PIK3CA exon 20 mutation + HR positive • PIK3CA exon 9 mutation + HR positive
    over3years
    INST 1204: PIK3CA Mutations as Biomarkers for Metastasis in Colon Cancer (clinicaltrials.gov)
    P=N/A, N=750, Completed, New Mexico Cancer Care Alliance | Recruiting --> Completed
    Trial completion
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
    |
    KRAS mutation • BRAF mutation • PIK3CA mutation • PIK3CA exon 20 mutation + HR positive • PIK3CA exon 9 mutation + HR positive