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    DRUG CLASS:

    PIGF inhibitor

    Related drugs:
    3d
    4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration (clinicaltrials.gov)
    P3, N=480, Active, not recruiting, 4D Molecular Therapeutics | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Eylea (aflibercept intravitreal)
    4d
    A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related Macular Degeneration (clinicaltrials.gov)
    P3, N=356, Not yet recruiting, Qilu Pharmaceutical Co., Ltd.
    New P3 trial
    |
    Eylea (aflibercept intravitreal)
    5d
    ALVOEYE-HD: Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular Edema (clinicaltrials.gov)
    P3, N=256, Not yet recruiting, Alvotech Swiss AG
    New P3 trial
    |
    Eylea (aflibercept intravitreal)
    13d
    When the Air Gets Thin, and the Blood Gets Thick: Choroidal Hemangioma in High-Altitude Polycythemia. (PubMed, Cureus)
    The patient also received a single intravitreal Eylea (aflibercept) injection, following which the subretinal fluid subsided significantly...Chronic hypoxia-induced hyperviscosity may contribute to vascular dilation and permeability changes within the choroid. Recognition of this association is crucial for timely diagnosis and effective management of choroidal hemangioma to preserve vision.
    Journal
    |
    JAK2 (Janus kinase 2)
    |
    Eylea (aflibercept intravitreal)
    17d
    AVT29-GL-C01: Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants with Diabetic Macular Edema (2025-522231-34-00)
    P2/3, N=102, Not yet recruiting, Alvotech Swiss AG
    New P2/3 trial
    |
    Eylea (aflibercept intravitreal)
    20d
    AVT29-GL-C01: Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants with Diabetic Macular Edema (2025-522231-34-00)
    P2/3, N=11, Not yet recruiting, Alvotech Swiss AG
    New P2/3 trial
    |
    Eylea (aflibercept intravitreal)
    28d
    EarLy Treatment Response in nEoVascular Macular Degeneration With Eylea 8mg: ELEV8 A Prospective Observational Open Label Study Investigating the Fluid Dynamics During Early Response to Aflibercept 8mg in Patients With Exudative Age-related Macular Degeneration (AMD). (clinicaltrials.gov)
    P=N/A, N=50, Recruiting, Insel Gruppe AG, University Hospital Bern
    New trial
    |
    Eylea (aflibercept intravitreal)
    1m
    AFLIWEST: Retrospective Multicenter Real-world Observational Study of Switching to Aflibercept 8 mg in Patients With Refractory or Dependent Exudative Age-related Macular Degeneration (clinicaltrials.gov)
    P=N/A, N=100, Not yet recruiting, Nantes University Hospital
    New trial • Real-world evidence
    |
    Eylea (aflibercept intravitreal)
    1m
    4D-150-C004: A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration (4FRONT-2) (2025-521349-25-00)
    P2/3, N=298, Recruiting, 4d Molecular Therapeutics Inc.
    New P2/3 trial
    |
    Eylea (aflibercept intravitreal)
    1m
    Two initial aflibercept 8 mg loading doses in treatment-naive neovascular AMD (2025-523478-17-00)
    P4, N=50, Not yet recruiting, Medical University Of Graz
    New P4 trial
    |
    Eylea (aflibercept intravitreal)
    2ms
    The Eylea 8mg Switch Study (clinicaltrials.gov)
    P=N/A, N=50, Active, not recruiting, Vienna Institute for Research in Ocular Surgery
    New trial
    |
    Eylea (aflibercept intravitreal)
    2ms
    A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients with Polypoidal Choroidal Vasculopathy (PCV) (ChiCTR2500115109)
    P4, N=174, Not yet recruiting, Shanghai General Hospital; Shanghai General Hospital
    New P4 trial
    |
    Eylea (aflibercept intravitreal)