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DRUG CLASS:

PIGF inhibitor

DRUG CLASS:

PIGF inhibitor

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ziv-aflibercept IV (4)

ziv-aflibercept IV (4)

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No biomarker	Colorectal Cancer	No biomarker	Colorectal Cancer	ziv-aflibercept IV Sensitive: A1 - Approval ziv-aflibercept IV Sensitive : A1	ziv-aflibercept IV Sensitive: A1 - Approval ziv-aflibercept IV Sensitive : A1
No biomarker	Rectal Cancer	No biomarker	Rectal Cancer	ziv-aflibercept IV Sensitive: A2 - Guideline ziv-aflibercept IV Sensitive : A2	ziv-aflibercept IV Sensitive: A2 - Guideline ziv-aflibercept IV Sensitive : A2
No biomarker	Colon Cancer	No biomarker	Colon Cancer	FOLFIRI + ziv-aflibercept IV Sensitive: A2 - Guideline FOLFIRI + ziv-aflibercept IV Sensitive : A2	FOLFIRI + ziv-aflibercept IV Sensitive: A2 - Guideline FOLFIRI + ziv-aflibercept IV Sensitive : A2
BRAF mutation	Colorectal Cancer	BRAF mutation	Colorectal Cancer	ziv-aflibercept IV Sensitive: B - Late Trials ziv-aflibercept IV Sensitive : B	ziv-aflibercept IV Sensitive: B - Late Trials ziv-aflibercept IV Sensitive : B
MIF overexpression	Glioblastoma	MIF overexpression	Glioblastoma	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
CCL27 overexpression	Glioblastoma	CCL27 overexpression	Glioblastoma	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
PIGF-L	Glioblastoma	PIGF-L	Glioblastoma	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
CXCL10 overexpression	Glioblastoma	CXCL10 overexpression	Glioblastoma	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
NRAS mutation	Colorectal Cancer	NRAS mutation	Colorectal Cancer	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3
BRAF mutation	Colorectal Cancer	BRAF mutation	Colorectal Cancer	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3	aflibercept intravitreal Sensitive: C3 – Early Trials aflibercept intravitreal Sensitive : C3