^
    2d
    Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer (clinicaltrials.gov)
    P1, N=5, Active, not recruiting, Roswell Park Cancer Institute | Recruiting --> Active, not recruiting | N=12 --> 5
    Enrollment closed • Enrollment change
    |
    Opdivo (nivolumab) • Photofrin (porfimer sodium)
    2ms
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=5, Active, not recruiting, Roswell Park Cancer Institute | Suspended --> Active, not recruiting | N=16 --> 5 | Trial completion date: Mar 2025 --> Jan 2026 | Trial primary completion date: Mar 2025 --> Feb 2024
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Photofrin (porfimer sodium)
    3ms
    Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma (clinicaltrials.gov)
    P2, N=102, Recruiting, Abramson Cancer Center at Penn Medicine | Trial completion date: Dec 2024 --> Jun 2025 | Trial primary completion date: May 2024 --> Dec 2024
    Trial completion date • Trial primary completion date
    |
    Photofrin (porfimer sodium)
    3ms
    Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer (clinicaltrials.gov)
    P1/2, N=19, Active, not recruiting, Roswell Park Cancer Institute | Recruiting --> Active, not recruiting | N=65 --> 19 | Trial primary completion date: Feb 2030 --> Nov 2023
    Enrollment closed • Enrollment change • Trial primary completion date • Endobronchial ultrasound • Metastases
    |
    Photofrin (porfimer sodium)
    4ms
    Comprehensive analysis of hub genes associated with cisplatin-resistance in ovarian cancer and screening of therapeutic drugs through bioinformatics and experimental validation. (PubMed, J Ovarian Res)
    This study reveals changes in the expression level of some genes associated with cisplatin-resistant ovarian cancer. In addition, a new small molecule compound was identified for the treatment of cisplatin-resistant ovarian cancer.
    Journal
    |
    B2M (Beta-2-microglobulin) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • NDRG1 (N-Myc Downstream Regulated 1) • SLIT2 (Slit Guidance Ligand 2) • ANK3 (Ankyrin 3)
    |
    cisplatin • Photofrin (porfimer sodium)
    5ms
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=16, Suspended, Roswell Park Cancer Institute | Recruiting --> Suspended
    Trial suspension
    |
    PD-L1 (Programmed death ligand 1)
    |
    Photofrin (porfimer sodium)
    8ms
    Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer (clinicaltrials.gov)
    P1, N=12, Recruiting, Roswell Park Cancer Institute | Phase classification: P2 --> P1 | N=82 --> 12
    Phase classification • Enrollment change • Metastases
    |
    Opdivo (nivolumab) • Photofrin (porfimer sodium)
    10ms
    Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer (clinicaltrials.gov)
    P2, N=82, Recruiting, Roswell Park Cancer Institute | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Erbitux (cetuximab) • cisplatin • carboplatin • 5-fluorouracil • Photofrin (porfimer sodium)
    12ms
    Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery (clinicaltrials.gov)
    P1, N=9, Active, not recruiting, Roswell Park Cancer Institute | Recruiting --> Active, not recruiting | Trial completion date: Mar 2025 --> Nov 2025 | Trial primary completion date: Mar 2025 --> Nov 2023
    Enrollment closed • Trial completion date • Trial primary completion date • Surgery
    |
    Photofrin (porfimer sodium)
    1year
    Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials. (PubMed, Pharmaceutics)
    In lung cancer, porfimer sodium, chlorin e6, and verteporfin have shown promising results in preclinical studies and clinical trials...PDT with temoporfin, redaporfin, photochlor, and IR700 shows potential in early stage larynx cancer and recurrent head and neck carcinoma...In conclusion, PDT continues to evolve as a promising cancer treatment strategy, with ongoing research spanning from fundamental investigations to clinical trials, exploring various photosensitizers and treatment combinations. This review sheds light on the recent advancements in PDT for cancer therapy and highlights its potential for personalized and targeted treatments.
    Review • Journal
    |
    Visudyne (verteporfin) • Foscan (temoporfin) • Photofrin (porfimer sodium)
    1year
    Photosensitizers for Photodynamic Therapy of Brain Cancers-A Review. (PubMed, Brain Sci)
    The most commonly used photosensitizers include 5-aminolevulinic acid for the enzymatic generation of protoporphyrin IX, Temoporfin-THPC, Photofrin, Hypericin and Talaporfin. An overview of all three generations of photosensitizers is presented. Along with an indication of the limitations of the treatment of brain tumors, intraoperative photodynamic therapy and its possibilities are described as an alternative therapeutic method.
    Review • Journal
    |
    Foscan (temoporfin) • Litx (talaporfin) • Photofrin (porfimer sodium)
    1year
    Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy. (PubMed, Cancer Res Commun)
    In this bedside-to-bench study, Photofrin-based PDT introduced the possibility of achieving a long-term response in murine models of MPM tumors that were surgically debulked by 60% to 90%...Although mesothelioma is difficult to treat, we have shown that combining surgery with a form of radiation, photodynamic therapy, may help people with mesothelioma live longer. In this study, we demonstrate in mice that this regimen could be further improved by addressing the inflammation induced as a by-product of surgery.
    Journal
    |
    CD8 (cluster of differentiation 8)
    |
    Photofrin (porfimer sodium)
    over1year
    Excitation of a Single Compound by Light and Ultrasound Enhanced the Long-Term Cure of Mice Bearing Prostate Tumors. (PubMed, Int J Mol Sci)
    To overcome these problems, photodynamic therapy (PDT) has previously been investigated using Photofrin as a photosensitizer (PS)...Therefore, the reactive oxygen species (ROS) produced by SDT and PDT follow two distinct pathways, i.e., type I (oxygen independent) and type II (oxygen dependent), respectively, and results in significantly enhanced destruction of tumor cells. The preliminary in vitro and in vivo results in a PC3 cell line and tumor model indicate that the tumor specificality of the therapeutic agent(s) can be increased by targeting galectin-1 and galectin-3, known for their overexpression in prostate cancer.
    Preclinical • Journal
    |
    LGALS1 (Galectin 1)
    |
    Photofrin (porfimer sodium)
    over1year
    Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer (clinicaltrials.gov)
    P1/2, N=65, Recruiting, Roswell Park Cancer Institute | N=36 --> 65 | Trial completion date: Feb 2024 --> Feb 2030 | Trial primary completion date: Feb 2024 --> Feb 2030
    Enrollment change • Trial completion date • Trial primary completion date • Endobronchial ultrasound • Metastases
    |
    Photofrin (porfimer sodium)
    over1year
    A Monte Carlo simulation for Moving Light Source in Intracavity PDT. (PubMed, Proc SPIE Int Soc Opt Eng)
    PEDSy-MC is accompanied by a dose-cavity visualization tool that allows real-time inspection of dose values of the treated cavity in 2D and 3D, which will be expanded to ongoing clinical trials at PSM. PSM has developed a technology to measure 8-detectors in a pleural cavity phantom using Photofrin-mediated PDT that has been used during validation.
    Journal
    |
    Photofrin (porfimer sodium)
    over1year
    Homology Modeling, Screening, and Identification of Potential FOXO6 Inhibitors Curtail Gastric Cancer Progression: an In Silico Drug Repurposing Approach. (PubMed, Appl Biochem Biotechnol)
    The major three docking software packages were used to analyze the scoring/H-bonding energy and intermolecular interactions. Based on the results, we concluded that FOXO6 was upregulated in gastric cancer and the ligand porfimer sodium emerges as a promising potential FOXO6 inhibitor to curtail gastric cancer progression.
    Journal
    |
    FOXO3 (Forkhead box O3)
    |
    Photofrin (porfimer sodium)
    over1year
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=16, Recruiting, Roswell Park Cancer Institute | Trial completion date: Sep 2023 --> Mar 2025 | Trial primary completion date: Sep 2023 --> Mar 2025
    Trial completion date • Trial primary completion date
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Photofrin (porfimer sodium)
    almost2years
    Ras-transfected human mammary tumour cells are resistant to photodynamic therapy by mechanisms related to cell adhesion. (PubMed, Life Sci)
    Knowledge of the mechanisms of resistance to photodamage in Ras-overexpressing cells may lead to the optimization of the combination of PDT with other treatments.
    Journal
    |
    CDH1 (Cadherin 1) • VCL (Vinculin)
    |
    CDH1 expression
    |
    cisplatin • 5-fluorouracil • doxorubicin hydrochloride • methotrexate • mitomycin • Foscan (temoporfin) • Photofrin (porfimer sodium)
    over2years
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=16, Recruiting, Roswell Park Cancer Institute | Trial completion date: Dec 2023 --> Sep 2023 | Trial primary completion date: Dec 2022 --> Sep 2023
    Trial completion date • Trial primary completion date
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Photofrin (porfimer sodium)
    almost3years
    Integrated Transcriptome Analysis Reveals the Impact of Photodynamic Therapy on Cerebrovascular Endothelial Cells. (PubMed, Front Oncol)
    To understand the impact of photodynamic interventions on cerebrovascular endothelial cells, we evaluated the dosage-dependent impact of porfimer sodium-mediated PDT on B.END3 cells using flow cytometer, comet assay, RNA sequencing, and bioinformatics analysis...To further perform qRT-PCR assays, we find that TNF-α/NF-κB and KRAS pathways were substantially up-regulated, consistent with GSEA analysis. The current findings suggested that a low dosage of PDT intervention may be detrimental to the homeostasis of blood-brain barrier (BBB) by inducing the inflammatory response and affecting the expression of surface biomarkers.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • TNFA (Tumor Necrosis Factor-Alpha) • AURKB (Aurora Kinase B) • CCNA2 (Cyclin A2) • CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • MCM4 (Minichromosome Maintenance Complex Component 4) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CDC6 (Cell Division Cycle 6) • MCM5 (Minichromosome Maintenance Complex Component 5)
    |
    Photofrin (porfimer sodium)
    3years
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=16, Recruiting, Roswell Park Cancer Institute | Not yet recruiting --> Recruiting
    Clinical • Enrollment open
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Photofrin (porfimer sodium)
    over3years
    Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease (clinicaltrials.gov)
    P1, N=16, Not yet recruiting, Roswell Park Cancer Institute
    Clinical • New P1 trial
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Photofrin (porfimer sodium)
    over4years
    [VIRTUAL] Photofrin-based interstitial photodynamic therapy using a newly developed LED catheter for pancreatic cancer xenografts. (AACR-II 2020)
    Mini-LED based i-PDT also induced caspase-3-like activation following downregulation of Bcl-2 and upregulation of Bax protein levels in tumors, while it reduced cell proliferation and expression of VEGF.ConclusionsThe mini-LED based i-PDT with photofrin exhibited promising antitumor effects possibly via inducing apoptotic cell death in the pre-clinical xenograft study of pancreatic cancer, which appeared to be more potent than conventional i-PDTs. Our data provide preliminary evidence on the great promise of mini-LED based i-PDT in patients with pancreatic cancer.
    IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • VEGFA (Vascular endothelial growth factor A) • CASP3 (Caspase 3)
    |
    Photofrin (porfimer sodium)