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DRUG:

PF-06753512

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Company:

Pfizer

Drug class:

CTLA4 inhibitor, Immunostimulant, IL-2 stimulant

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over1year

First-in-human, phase 1 study of PF-06753512, a vaccine-based immunotherapy regimen (VBIR), in non-metastatic hormone-sensitive biochemical recurrence and metastatic castration-resistant prostate cancer (mCRPC). (PubMed, J Immunother Cancer)

PrCa VBIR overall demonstrated safety signals similar to other ICI combination trials; significant side effects were seen in some patients with BCR. It stimulated antigen-specific immunity across all cohorts and resulted in modest antitumor activity in patients with BCR without using ADT.

over 1 year ago

P1 data • Clinical Trial,Phase I • Journal • Metastases

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PSCA (Prostate Stem Cell Antigen 2)

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Imjudo (tremelimumab) • sasanlimab (PF-06801591) • PF-06753512