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BIOMARKER:

PAK4 overexpression

i
Other names: PAK4, P21 (RAC1) Activated Kinase 4, P21 Protein (Cdc42/Rac)-Activated Kinase 4, Serine/Threonine-Protein Kinase PAK 4, P21(CDKN1A)-Activated Kinase 4, Protein Kinase Related To S. Cerevisiae STE20, Effector For Cdc42Hs, P21-Activated Kinase 4
Entrez ID:
Related biomarkers:
6ms
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1. (PubMed, Nat Commun)
Interestingly, PAK4 protein levels are significantly suppressed by fasting, largely through either cAMP/PKA- or Sirt1-mediated ubiquitination and proteasome degradation. In this way, our findings provide evidence for a PAK4-NCoR1/PPARα signaling pathway that regulates fatty acid β-oxidation and ketogenesis.
Journal
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PAK4 (P21 (RAC1) Activated Kinase 4) • NCOR1 (Nuclear Receptor Corepressor 1) • SIRT1 (Sirtuin 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)
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PAK4 overexpression
1year
The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway. (PubMed, Clin Transl Oncol)
This study demonstrates that the PAK4 regulates the biological behaviors of OSCC by PI3K-AKT signaling pathway, and these findings might provide a novel strategy for OSCC treatment.
Journal
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PAK4 (P21 (RAC1) Activated Kinase 4)
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PAK4 overexpression
1year
LncRNA IGFL2-AS1 as a ceRNA Promotes HCT116 Cell Malignant Proliferation via the miR-433-3p/PAK4 Axis. (PubMed, Turk J Gastroenterol)
LncRNA IGFL2-AS1 was abundantly expressed in colorectal cancer tissues and cells, and comparatively bound to miR433-3p to facilitate PAK4 transcription, thus promoting HCT116 cell malignant proliferation.
Journal
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PAK4 (P21 (RAC1) Activated Kinase 4) • IGF2 (Insulin-like growth factor 2) • RAC1 (Rac Family Small GTPase 1) • PAK1 (p21 (RAC1) activated kinase 1) • IGFL2-AS1 (IGFL2 Antisense RNA 1) • MIR433 (MicroRNA 433)
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PAK4 overexpression
over1year
PAK4 expression is associated with the prognosis in non-small cell lung cancer. (PubMed, Medicine (Baltimore))
Cox regression analysis explained that PAK4 expression was associated with the prognosis of NSCLC patients (P = .024; HR, 3.104; 95% CI, 1.164-8.278). In a word, PAK4 was highly expressed in NSCLC tissues and could act as a prognostic factor for NSCLC patients.
Journal
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PAK4 (P21 (RAC1) Activated Kinase 4)
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PAK4 overexpression
over1year
MiR-199a/b-3p inhibits colorectal cancer cell proliferation, migration and invasion through targeting PAK4 and BCAR3. (PubMed, Eur J Med Res)
These results provided a new multi-targeted cite for cancerous suppressant to improve the prognosis of CRC inpatients.
Journal
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PAK4 (P21 (RAC1) Activated Kinase 4) • MIR199A (MicroRNA 199a)
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PAK4 overexpression
2years
Interfering with pak4 Protein Expression Affects Osteosarcoma Cell Proliferation and Migration. (PubMed, Biomed Res Int)
PAK4 can also activate Erk expression in OS cells and induce EMT. Interfering with PAK4 protein expression has been shown to affect osteosarcoma proliferation and migration.
Journal
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CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • CDK6 (Cyclin-dependent kinase 6) • MAPK1 (Mitogen-activated protein kinase 1) • CDK2 (Cyclin-dependent kinase 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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CCND1 expression • PAK4 overexpression • CCNE1 expression • CDK2 expression • CDK6 expression
over2years
Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma. (PubMed, Investig Clin Urol)
(pPAK4 may be a more accurate prognostic factor than total PAK4 in RCC patients. This marker would be useful for identifying patients with pathologically localized disease who may require further interventions.
Clinical • Journal
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PAK4 (P21 (RAC1) Activated Kinase 4)
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PAK4 overexpression