The case shows the significance of following prolactin levels in children who are on risperidone therapy particularly those who are non-verbal or those who cannot communicate any discomfort. Clinicians are to remember that risperidone leads to hyperprolactinemia which can simulate pituitary malfunctions. Early identification, educating caregivers, and substitution of prolactin-stimulating drugs with prolactin-sparing ones like olanzapine will allow avoiding unnecessary investigations and enhancing the clinical and family outcomes.

1 month ago

Journal

PRL (Prolactin)

olanzapine

SPARROW-GC: A Simplified Regimen to Prevent Nausea and Vomiting Using Netupitant/Palonosetron in Germ Cell Cancer Patients Receiving Chemotherapy (clinicaltrials.gov)

P1, N=10, Not yet recruiting, Ottawa Hospital Research Institute

1 month ago

New P1 trial

cisplatin • dexamethasone • olanzapine • ondansetron

MAIA: Maternal And Infant Antipsychotic Study (clinicaltrials.gov)

P=N/A, N=74, Recruiting, Icahn School of Medicine at Mount Sinai | N=200 --> 74 | Trial primary completion date: Jun 2027 --> Jan 2028

1 month ago

Enrollment change • Trial primary completion date

olanzapine

OLIVE: Olanzapine for weight loss prevention in patients with head and neck cancer undergoing curative intent chemotherapy with radiotherapy (ACTRN12626000719336)

P2, N=57, Not yet recruiting, Fiona Stanley Hospital

1 month ago

New P2 trial

olanzapine

2ms

Olanzapine in the Prevention and Treatment of Anorexia-Cachexia Syndrome in Patients Receiving Neoadjuvant/Preoperative Chemotherapy (clinicaltrials.gov)

P3, N=100, Recruiting, Blokhin's Russian Cancer Research Center

2 months ago

New P3 trial

olanzapine

2ms

DREAMS-Phen: Study Comparing Antipsychotic Dose Reduction vs. Maintenance Treatment in Patients With Schizophrenia Spectrum Disorder: a Personalized Medicine Approach (clinicaltrials.gov)

P2, N=288, Not yet recruiting, University Hospital, Strasbourg, France | Initiation date: Jan 2026 --> Oct 2026

2 months ago

Trial initiation date

Clopixol (zuclopenthixol) • olanzapine

2ms

Olanzapine Dose Comparison for the Prevention of HER-INV: A Network Meta-Analysis (clinicaltrials.gov)

P=N/A, N=2000, Completed, Shandong Cancer Hospital and Institute | Recruiting --> Completed

2 months ago

Trial completion

olanzapine

2ms

GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer (clinicaltrials.gov)

P2, N=26, Not yet recruiting, University of Illinois at Chicago

2 months ago

New P2 trial

olanzapine

3ms

Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area (clinicaltrials.gov)

P=N/A, N=100, Not yet recruiting, University of Alabama at Birmingham

3 months ago

New trial • Adverse events

olanzapine

3ms

Olanzapine Impact on First-line Immunotherapy for Advanced EGFR-negative NSCLC (clinicaltrials.gov)

P2, N=156, Recruiting, Second Affiliated Hospital of Nanchang University | Not yet recruiting --> Recruiting | Trial completion date: May 2028 --> May 2027 | Trial primary completion date: Dec 2027 --> Dec 2026

3 months ago

Enrollment open • Trial completion date • Trial primary completion date • IO biomarker

EGFR (Epidermal growth factor receptor)

Opdivo (nivolumab) • olanzapine

3ms

Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications (clinicaltrials.gov)

P3, N=380, Recruiting, Minerva Neurosciences

3 months ago

New P3 trial

olanzapine

3ms

An Exploratory Study on Efficacy and Safety of Fosaprepitant and Palonosetron Hydrochloride for Injection in Preventing CINV From Multi-Agent HEC (clinicaltrials.gov)

P4, N=200, Recruiting, Shanghai 6th People's Hospital | Not yet recruiting --> Recruiting

3 months ago

Enrollment open

dexamethasone injection • fosaprepitant • olanzapine