^
    over3years
    Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma. (PubMed, Oncotarget)
    RNAi inhibition of RAD52-dependent HR on the other hand potentiated the efficacy of a novel BETi ODM-207. Together these results describe the first ever CAC case with a BRCAness genetic background, evaluate combinatorial DNA repair targeting, and provide a data resource for further analyses of DNA repair targeting in PALB2 deficient cancers.
    Preclinical • Journal
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PALB2 (Partner and localizer of BRCA2) • RAD51 (RAD51 Homolog A) • RAD52 (RAD52 Homolog DNA Repair Protein)
    |
    ODM-207