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NKT2152
i
Other names: NKT2152, NKT-2152, NKT 2152, HS10516, HS-10516, HS 10516
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Company:
Jiangsu Hansoh Pharma, NiKang Therap
Drug class:
HIF-2α inhibitor
Related drugs:
6d
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver) (clinicaltrials.gov)
P1/2, N=518, Recruiting, Hoffmann-La Roche | Trial completion date: Aug 2026 --> Dec 2026 | Trial primary completion date: Aug 2026 --> Dec 2026
Trial completion date • Trial primary completion date • Metastases
|
PD-L1 (Programmed death ligand 1)
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • amezalpat (TPST-1120) • Actemra IV (tocilizumab) • tiragolumab (RG6058) • IO-108 • NKT2152 • muzastotug (ADG126) • tobemstomig (RG6139)
2ms
NKT2152-202: Ph2 Study NKT2152 with Palbociclib & Sasanlimab in Subjects with Advanced Clear Cell Renal Cell Carcinoma (ccRcc) (clinicaltrials.gov)
P2, N=172, Active, not recruiting, NiKang Therapeutics, Inc. | Recruiting --> Active, not recruiting | Trial completion date: Sep 2026 --> Jun 2026 | Trial primary completion date: Jun 2026 --> Jun 2025
Enrollment closed • Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
Ibrance (palbociclib) • sasanlimab (PF-06801591) • NKT2152
2ms
NKT2152-101: A Study of NKT2152, a HIF2α Inhibitor, in Patients with Advanced Clear Cell Renal Cell Carcinoma (clinicaltrials.gov)
P1/2, N=128, Active, not recruiting, NiKang Therapeutics, Inc. | Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2024 --> May 2025
Enrollment closed • Trial primary completion date • Metastases
|
PD-L1 (Programmed death ligand 1)
|
NKT2152
4ms
A Study of HS-10516 in Patients With VHL Syndrome Associated Tumors (clinicaltrials.gov)
P1, N=60, Recruiting, Jiangsu Hansoh Pharmaceutical Co., Ltd.
New P1 trial
|
NKT2152
7ms
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver) (clinicaltrials.gov)
P1/2, N=506, Recruiting, Hoffmann-La Roche | Trial completion date: Dec 2025 --> Aug 2026 | Trial primary completion date: Dec 2025 --> Aug 2026
Trial completion date • Trial primary completion date
|
PD-L1 (Programmed death ligand 1)
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • amezalpat (TPST-1120) • Actemra IV (tocilizumab) • tiragolumab (RG6058) • NKT2152 • muzastotug (ADG126) • tobemstomig (RG6139)
1year
A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma (clinicaltrials.gov)
P1/2, N=128, Recruiting, NiKang Therapeutics, Inc. | N=98 --> 128
Enrollment change
|
PD-L1 (Programmed death ligand 1)
|
NKT2152
over1year
Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc) (clinicaltrials.gov)
P2, N=172, Not yet recruiting, NiKang Therapeutics, Inc.
New P2 trial • Combination therapy • Metastases
|
Ibrance (palbociclib) • sasanlimab (PF-06801591) • NKT2152
over1year
Clinical • P1/2 data • Metastases
|
NKT2152
2years
A Phase 1/2, Open Label Dose- Escalation and Expansion Trial of NKT2152, an orally administered HIF2α inhibitor, to investigate safety. PK, PD and clinical activity in patients with advanced ccRCC (KCRS 2022)
The study is currently actively accruing in the United States. Methods N/A Results N/A Conclusions N/A
Clinical • P1/2 data
|
PD-L1 (Programmed death ligand 1) • VHL (von Hippel-Lindau tumor suppressor)
|
NKT2152
3years
A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma (clinicaltrials.gov)
P1/2, N=98, Recruiting, NiKang Therapeutics, Inc.
New P1/2 trial
|
PD-L1 (Programmed death ligand 1)
|
NKT2152
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