^
    4years
    Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti-tumor activity in Multiple Myeloma. (PubMed, Eur J Haematol)
    The dual inhibition of BET and CBP/EP300 has potential therapeutic benefits for patients with MM.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • EP300 (E1A binding protein p300) • IRF4 (Interferon regulatory factor 4)
    |
    JQ-1 • birabresib (OTX015) • molibresib (GSK525762) • I-BET151 • EP31670 • NEO1132