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    1year
    A novel C-terminal of HSP90 inhibitor NCT-547 eliminates cancer stem-like subpopulation in triple-negative breast cancer (AACR 2023)
    It is noteworthy that NCT-547 did not affect markers of hepatic and renal acute toxicity and was not cytotoxic in non-malignant cells. NCT-547 may therefore have potential to address current limitations in the treatment of TNBC.
    Clinical
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • HSF1 (Heat Shock Transcription Factor 1)
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    NCT-547