MUC16 elevation

P=N/A, N=2000, Recruiting, Alliance for Clinical Trials in Oncology | Trial completion date: Feb 2025 --> Feb 2027 | Trial primary completion date: Jan 2025 --> Jan 2026

P=N/A, N=363, Active, not recruiting, Assistance Publique - Hôpitaux de Paris | Trial primary completion date: May 2023 --> May 2024

The patient was treated with methylprednisolone and Plaquenil, with careful monitoring for potential complications...The unusual initial presentation underscores the importance of considering PPMS in differential diagnoses to avoid misdiagnosis and unnecessary invasive procedures. Early recognition and appropriate management are essential for optimizing patient outcomes in this rare and complex syndrome.

The mechanism in this case involved increased mobility of the left adnexa after hysterectomy and tumor infiltration near the inguinal canal. This case highlights the importance of considering fallopian tube carcinoma as a differential diagnosis when evaluating inguinal hernias, particularly in high-risk patients.

At the same time, the clinician could monitor the patient's serum CA125 level changes to assist in the judgment of the efficacy of the original disease. This report extends the understanding of WM and the application of CA125.

P1/2, N=50, Recruiting, Xing Xie | Trial primary completion date: Jan 2024 --> Dec 2024

Preoperative CEA, CA15-3, and CA125 levels may have different prognostic effects on patients with different molecular subtypes. Particularly, preoperative elevated levels of CEA have a significant adverse impact on the prognosis of luminal A and triple-negative patients, while preoperative elevated levels of CA15-3 have an adverse effect on the prognosis of luminal A and HER-positive patients.

These markers may offer a significant lead time over imaging, potentially enabling earlier intervention. Further research is needed to validate these findings.

She underwent laparoscopy with histopathological examination, confirming the diagnosis of tuberculosis, showing giant cell granulomas with caseous necrosis. A favorable outcome was observed on all fronts after antitubercular treatment.

We present a 39-centimeter thecoma with ascites and elevated Ca-125 values which is compatible with an atypical/incomplete Meigs' syndrome. Giant ovarian masses with elevated Ca-125 values and ascites are an alarming combination, although Gynecologists should be aware that there are also benign entities that mimic advanced stage ovarian cancer.

Initial carboplatin 5 AUC and paclitaxel 175 mg/m2 administration resulted in improvement in performance status with ECOG score of 1, alleviation of dyspnea, reduction in pleural effusion 1 week after chemotherapy, with minimal effusion observed at 3 weeks, and Ca-125 levels decreased to 33.6 U/mL thereafter. Empiric chemotherapy using carboplatin and paclitaxel is a feasible option for managing CUP with MPE mimicking gynecological malignancies with elevated Ca-125 and Ca 15-3 markers; initiating chemotherapy in poor performance status patients is beneficial with proper clinical judgment.

P=N/A, N=2640, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Jun 2026