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    BIOMARKER:

    MUC16 elevation

    i
    Other names: MUC16, Mucin 16, Cell Surface Associated, Ovarian Cancer-Related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125, Mucin-16, CA125, CA125 Ovarian Cancer Antigen, Mucin-16 Short Isoform, Mucin-16 Long Isoform, CA-125, MUC-16
    Entrez ID:
    94025
    Related biomarkers:
    Expression
    Mutation
    Others
    Apply
    Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA) (NCT05445778)
    Phase 3
    ImmunoGen, Inc.
    Recruiting
    Last update posted :
    06/13/2024
    Initiation :
    12/27/2022
    Primary completion :
    03/01/2027
    Completion :
    04/01/2029
    FOLR1 • BRCA • MUC16
    |
    FOLR1 expression • MUC16 elevation
    |
    Avastin (bevacizumab) • Elahere (mirvetuximab soravtansine-gynx)
    Phase II Investigation of Pembrolizumab in Combination With Bevacizumab and Oral Cyclophosphamide in Patients With High Grade Ovarian Cancer and Surgically Documented Minimal Residual Disease After Frontline Therapy (NCT06083844)
    Phase 2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    05/30/2024
    Initiation :
    12/12/2023
    Primary completion :
    09/30/2025
    Completion :
    09/30/2027
    BRCA1 • BRCA2 • MUC16
    |
    MUC16 elevation
    |
    Keytruda (pembrolizumab) • Avastin (bevacizumab) • cyclophosphamide
    Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection (NCT05334069)
    Phase N/A
    Alliance for Clinical Trials in Oncology
    Recruiting
    Last update posted :
    05/23/2024
    Initiation :
    08/01/2022
    Primary completion :
    01/31/2025
    Completion :
    02/01/2025
    MUC16
    |
    MUC16 elevation
    Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer (NCT05051722)
    Phase N/A
    Mayo Clinic
    Recruiting
    Last update posted :
    05/16/2024
    Initiation :
    08/03/2021
    Primary completion :
    06/30/2025
    Completion :
    12/30/2025
    MUC16
    |
    MUC16 elevation
    Trial on Radical Upfront Surgery in Advanced Ovarian Cancer (FRAGILE) (NCT02828618)
    Phase N/A
    AGO Study Group
    Active, not recruiting
    Last update posted :
    05/09/2024
    Initiation :
    07/01/2016
    Primary completion :
    12/01/2024
    Completion :
    02/01/2025
    MUC16
    |
    MUC16 elevation
    Combination Therapy for Recurrent Ovarian Cancer (NCT05610735)
    Phase 1/2
    Sham Sunder Kakar
    Recruiting
    Last update posted :
    04/24/2024
    Initiation :
    05/01/2024
    Primary completion :
    11/01/2026
    Completion :
    11/01/2027
    MUC16
    |
    MUC16 elevation
    |
    pegylated liposomal doxorubicin
    Recombinant Measles Virus Vaccine Therapy and Oncolytic Virus Therapy in Treating Patients With Progressive, Recurrent, or Refractory Ovarian Epithelial Cancer or Primary Peritoneal Cancer (NCT00408590)
    Phase 1
    Mayo Clinic
    Completed
    Last update posted :
    01/15/2024
    Initiation :
    04/19/2004
    Primary completion :
    08/01/2012
    Completion :
    11/07/2017
    MUC16 • CD4
    |
    MUC16 elevation
    Vaccine Therapy in Stage II, III, or IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers (NCT00803569)
    Phase 1
    Ludwig Institute for Cancer Research
    Completed
    Last update posted :
    10/04/2023
    Initiation :
    11/14/2008
    Primary completion :
    01/24/2011
    Completion :
    01/24/2011
    MUC16 • CTAG1B • CTAG2
    |
    MUC16 elevation
    |
    Leukine (sargramostim)
    Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers (NCT02020707)
    Phase 1
    Mayo Clinic
    Active, not recruiting
    Last update posted :
    10/02/2023
    Initiation :
    02/24/2014
    Primary completion :
    06/30/2024
    Completion :
    06/30/2025
    MUC16
    |
    MUC16 elevation
    |
    Avastin (bevacizumab) • cisplatin • albumin-bound paclitaxel • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Zirabev (bevacizumab-bvzr) • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar)
    IN10018 in Combination With Pegylated Liposomal Doxorubicin (PLD) vs. Placebo in Combination With PLD for the Treatment of Platinum-resistant Recurrent Ovarian Cancer (NCT06014528)
    Phase 2
    InxMed (Shanghai) Co., Ltd.
    Recruiting
    Last update posted :
    08/28/2023
    Initiation :
    09/06/2022
    Primary completion :
    12/01/2024
    Completion :
    12/01/2025
    MUC16
    |
    MUC16 elevation
    |
    pegylated liposomal doxorubicin • ifebemtinib (IN10018)
    Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (NCT02122185)
    Phase 2
    University of Chicago
    Suspended
    Last update posted :
    08/28/2023
    Initiation :
    02/25/2015
    Primary completion :
    02/25/2025
    Completion :
    02/25/2025
    CEACAM5 • MUC16
    |
    MUC16 elevation
    |
    metformin