^
    over1year
    CIRCULATING TUMOR DNA (CTDNA) ANALYSES AND RESISTANCE MECHANISMS EXPLORATION OF KIT-MUTANT GASTROINTESTINAL STROMAL TUMORS (GISTS) TREATED WITH AVAPRITINIB OR RIPRETINB (CTOS 2023)
    Different KIT mutation types and signaling pathways atlerations were detected in progression samples of KIT-mutant GISTs after avapritinib or ripretinib failure compared with baseline, which may be associated with mechanism of resistance.
    Circulating tumor DNA • Stroma
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    KIT (KIT proto-oncogene, receptor tyrosine kinase)
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    KIT mutation • KIT exon 11 mutation • KIT exon 9 mutation • KIT exon 13 mutation • KIT exon 17 mutation • KIT exon 14 mutation
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    Ayvakit (avapritinib) • Qinlock (ripretinib)