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    DRUG:

    K-1299

    i
    Other names: K-1299
    Associations

    News

    Trials
    Company:
    Kuda Therap
    Drug class:
    HIF-2α inhibitor
    Related drugs:
    Associations

    News

    Trials
    over3years
    USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. (PubMed, Sci Adv)
    TET2 is monoubiquitylated at K1299, which promotes its activity...Deletion of Usp15 in melanoma stimulates chemokine expression and TILs in a TET2-dependent manner, leading to increased response to immunotherapy and extended life span of tumor-bearing mice. These results reveal a previously unknown regulator of TET2 activity and suggest USP15 as a potential therapeutic target for immunotherapy of solid tumors.
    Journal
    |
    TET2 (Tet Methylcytosine Dioxygenase 2)
    |
    K-1299