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    Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models. (PubMed, World J Gastrointest Oncol)
    BET could be a potential effective drug target for suppressing CRC growth, and the BET inhibitor JAB-8263 can effectively suppress c-MYC expression and exert anti-tumor activity in CRC models.
    Preclinical • Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • ANXA5 (Annexin A5)
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    MYC expression
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    JAB-8263