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    BIOMARKER:

    IR overexpression

    i
    Other names: IR, Insulin receptor
    Entrez ID:
    3643
    Related biomarkers:
    Others
    12ms
    Insulin receptor loss impairs mammary tumorigenesis in mice. (PubMed, Cell Rep)
    INSR upholds a bioenergetic phenotype in non-transformed mammary epithelial cells, independent of its kinase activity. Similarity of phenotypes elicited by deletion of one or both copies of INSR suggest a dose-dependent threshold for INSR impact on mammary tumorigenesis.
    Preclinical • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • IR (Insulin receptor)
    |
    IR overexpression
    almost2years
    Overexpression of Insulin Receptor Substrate 1 (IRS1) Relates to Poor Prognosis and Promotes Proliferation, Stemness, Migration, and Oxidative Stress Resistance in Cholangiocarcinoma. (PubMed, Int J Mol Sci)
    The findings indicate that IRS1 is a key molecule in the connection between oxidative stress and CCA progression. Therefore, IRS1 and its related genes can be used as prognostic markers and therapeutic targets for CCA therapy.
    Journal
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    IRS1 (Insulin Receptor Substrate 1)
    |
    IR overexpression
    almost4years
    Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer. (PubMed, Matrix Biol Plus)
    Thus, our findings provide the first characterization of the molecular cross-talk between DDR1 and the IGF-I system and could lead to the identification of novel targets for therapeutic intervention in bladder cancer. Moreover, the expression profiles of IGF-IR, IR-A, DDR1, and downstream effectors could serve as a novel biomarker signature with diagnostic and prognostic significance.
    Journal
    |
    IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2) • IR (Insulin receptor)
    |
    IR overexpression