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DRUG:

IO102

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Other names: IO102, IDOlong, IO 102, 21-mer IDO-derived peptide vaccine
Associations
Company:
IO Biotech
Drug class:
IDO inhibitor
Associations
1year
KIEO: Neoadjuvant Pembrolizumab and IO102-103 for Squamous Cell Carcinoma of the Head and Neck (SCCHN). (clinicaltrials.gov)
P2, N=15, Recruiting, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Not yet recruiting --> Recruiting
Enrollment open
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Keytruda (pembrolizumab) • IO102
4years
[VIRTUAL] Clinical efficacy and immunity of combination therapy with nivolumab and IDO/PD-L1 peptide vaccine in patients with metastatic melanoma: A phase I/II trial (ESMO 2020)
Background The IDO/PD-L1 (IO102/IO103)1 peptide vaccine is a first-in-class immunomodulatory vaccine containing single IDO- and PD-L1-derived long peptide sequences designed to engage and activate IDO and PD-L1 specific T-cells mediating immune switch. Funding: Has not received any funding. Clinical trial identification: NCT03047928.
Clinical • P1/2 data • Late-breaking abstract • Combination therapy
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PD-L1 (Programmed death ligand 1)
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Opdivo (nivolumab) • IO102 • IO103