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CDX-585
i
Other names: CDX-585, BSI-585
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Company:
Biosion, Celldex
Drug class:
PD1 inhibitor, ILT-4 inhibitor
Related drugs:
11ms
A Study of CDX-585 in Patients With Advanced Malignancies (clinicaltrials.gov)
P1, N=130, Recruiting, Celldex Therapeutics | Not yet recruiting --> Recruiting
Enrollment open • Metastases
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CDX-585
1year
CDX-585, a novel bispecific antibody targeting PD-1 and ILT4 (AACR 2023)
(2022 Clin Cancer Res 28: 57-70) reported encouraging results of the initial clinical study combining the ILT4 antagonist mAb MK-4830 with pembrolizumab. Doses of CDX-585 up to 60 mg/kg were well tolerated in cynomolgus macaques and displayed a favorable pharmacokinetic profile. Together these data demonstrate that CDX-585 effectively combines PD-1 and ILT4 blockade into one molecule with favorable biophysical and functional characteristics supporting the initiation of a dose-escalation clinical trial in patients with advanced solid tumors.
PD(L)-1 Biomarker • IO biomarker
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CD40 (CD40 Molecule)
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PD-L1 expression
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Keytruda (pembrolizumab) • CDX-585 • MK-4830
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