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BIOMARKER:

IDH1 wild-type + BRAF mutation

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Entrez ID:

Related biomarkers:

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IDH1 mutation + Chr del(1p) + Chr del(19q) (10)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

BRAF V600K + LDH elevation (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)

IDH1 mutation + NTRK1 fusion (2)

IDH1 mutation + NTRK2 fusion (2)

IDH1 mutation + NTRK3 fusion (2)

MYC overexpression + IDH1 mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

IDH1 mutation + FGFR2 fusion (1)

IDH1 mutation + FGFR2 rearrangement (1)

IDH1 mutation + MGMT promoter methylation (1)

IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)

IDH1 mutation + TMB-L (1)

IDH1 mutation + WT1 overexpression (1)

PD-L1 overexpression + BRAF mutation (0)

IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)

IDH1 mutation + Chr del(1p) + Chr del(19q) (10)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

BRAF V600K + LDH elevation (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)

IDH1 mutation + NTRK1 fusion (2)

IDH1 mutation + NTRK2 fusion (2)

IDH1 mutation + NTRK3 fusion (2)

MYC overexpression + IDH1 mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

IDH wild-type + FGFR3 S249C + TP53 V73fs (1)

IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)

IDH1 mutation + ATRX deletion + TP53 deletion (1)

IDH1 mutation + FGFR2 fusion (1)

IDH1 mutation + FGFR2 rearrangement (1)

IDH1 mutation + MGMT promoter methylation (1)

IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)

IDH1 mutation + TMB-L (1)

IDH1 mutation + WT1 overexpression (1)

PD-L1 overexpression + BRAF mutation (0)

IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)

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11ms

Analysis of Histomorphologic/Molecular Association and Immune Checkpoint Regulators in Epithelioid Glioblastoma and Pleomorphic Xanthoastrocytoma: Are These Tumors Potential Candidates for Immune Checkpoint Blockade? (PubMed, Appl Immunohistochem Mol Morphol)

This analysis highlights the homogenous molecular and immune profile of eGB and PXA, suggesting the possibility that histologically and molecularly, these two entities represent 2 ends of a continuous spectrum with PXAG3 lying in between. Higher upregulation of PDL1, CTLA-4, and increased tumor infiltrating lymphocytes in these tumors as compared with GB, IDH wt suggests potential candidature for immunotherapy.

11 months ago

Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker • Checkpoint block

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EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • ATRX (ATRX Chromatin Remodeler) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)

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PD-L1 expression • TP53 mutation • BRAF V600E • BRAF V600 • IDH1 mutation • EGFR amplification • CDKN2A deletion • IDH wild-type • CTLA4 expression • IDH1 wild-type + BRAF mutation • PD-L1 expression + CTLA4 expression