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    1year
    HZ-A-018, a novel inhibitor of Bruton tyrosine kinase, exerts anti-cancer activity and sensitizes 5-FU in gastric cancer cells. (PubMed, Front Pharmacol)
    Mechanismly, the combination of HZ-A-018 and 5-FU remarkably reduced the expression of RRM2, which played an essential role in proliferation and drug sensitivity in gastric cancer cells. In summary, our work demonstrated the stronger anti-cancer activity of HZ-A-018 than ACP-196 in gastric cancer cells, and revealed synergistic effects of HZ-A-018 and 5-FU combination probably through the inhibition of RRM2 via AKT/S6 pathway, thereby providing a promising therapeutic strategy in gastric cancer.
    Journal
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    BTK (Bruton Tyrosine Kinase) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
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    5-fluorouracil • Calquence (acalabrutinib) • HZ-A-018