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    BIOMARKER:

    HIF1A expression

    i
    Other names: HIF1A, bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8, Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    Entrez ID:
    3091
    Related biomarkers:
    Expression
    Mutation
    Fusion
    8d
    Benzo (A) pyrene exposure alters alveolar epithelial and macrophage cells diversity and induces antioxidant responses in lungs. (PubMed, Toxicol Rep)
    The expression of anti-inflammatory (NF-κB) was also significantly increased. In conclusion, BaP exposure induced an inflammatory response, altered alveolar epithelial cell and macrophage diversity, and increased antioxidant responses in the lungs.
    Journal
    |
    CD74 (CD74 Molecule) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • ITGAM (Integrin, alpha M) • CAT (Catalase)
    |
    HIF1A expression
    8d
    PDGFRB promotes dedifferentiation and pulmonary metastasis through rearrangement of cytoskeleton under hypoxic microenvironment in osteosarcoma. (PubMed, Cell Signal)
    Our results demonstrated that HIF1A up-regulated PDGFRB under hypoxic conditions, and PDGFRB regulated the actin cytoskeleton, a process likely linked to the activation of RhoA and the phosphorylation of, thereby promoting OS dedifferentiation and pulmonary metastasis.
    Journal
    |
    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • RHOA (Ras homolog family member A) • VCL (Vinculin)
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    PDGFRB overexpression • HIF1A expression
    9d
    TME-Activated MnO2/Pt Nanoplatform of Hydroxyl Radical and Oxygen Generation to Synergistically Promote Radiotherapy and MR Imaging of Glioblastoma. (PubMed, Int J Nanomedicine)
    In U87 tumor bearing mice model, we utilized MnO2/Pt nanocatalysis to enhance the therapeutic effect of radiotherapy on GBM. This approach represents a novel and effective strategy for enhancing radiotherapy in gliomas, thereby advancing the field of catalytic radiotherapy and glioma treatment.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    10d
    Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia. (PubMed, Sci Rep)
    Chromatin immunoprecipitation data confirmed that ACKR2 is directly regulated by HIF-1α at its promoter in B16-F10 melanoma cells. This study provides new key elements on how hypoxia can impair immune infiltration in the tumor microenvironment.
    Journal • IO biomarker
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression • SETD2 deletion
    11d
    Design, synthesis, molecular dynamic and gene silencing studies of novel therapeutic siRNAs HIF-1α in hypoxic cancer cells. (PubMed, Int J Biol Macromol)
    The aim of the present study is to understand the siRNA-hAgo2 interaction. It is also focused on the desiging of effective siRNA against HIF-1α.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • AGO2 (Argonaute RISC Catalytic Component 2)
    |
    HIF1A expression
    11d
    Temperature-responsive two-dimensional polydopamine hydrogel: Preparation, mechanisms, and applications in cancer treatment. (PubMed, Int J Biol Macromol)
    O2 released from the CSZP hydrogel mitigated solid tumor hypoxia and suppressed the expression of hypoxia-inducible factor-1α (HIF-1α), thereby augmenting the efficacy of photodynamic therapy (PDT). This temperature-responsive hydrogel represented a highly promising platform for the precise and controlled release of various therapeutics, thereby advancing the field of targeted disease treatment.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    14d
    Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. (PubMed, Front Cell Neurosci)
    Furthermore, the enhanced vascular coupling of Olig2+/NG2+/BLBP+ ASPs appears to be an adaptive response to hypoxic brain injury. This study provides new insights into the molecular characteristics of Olig2+/NG2+/BLBP+ ASPs and their potential role in the brain's response to hypoxic injury, contributing to our understanding of neurovascular unit dynamics in both development and pathological conditions.
    Preclinical • Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • SOX10 (SRY-Box 10) • FAP (Fibroblast activation protein, alpha) • SOX9 (SRY-Box Transcription Factor 9) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
    |
    HIF1A expression
    14d
    Plasmodium infection downregulates hypoxia‑inducible factor 1α expression to suppress the vascularization and tumorigenesis of liver cancer. (PubMed, Oncol Lett)
    HIF-1α was downregulated in both hepatic and tumor tissues upon Plasmodium infection, and HIF-1α overexpression rescued angiogenesis and tumor growth under the condition of Plasmodium infection. In conclusion, the results of the present study demonstrated the anti-angiogenic and anti-tumorigenic effects of Plasmodium infection on liver cancer through downregulating HIF-1α expression, indicating that Plasmodium parasites could be developed as an intervention strategy to restrain neo-angiogenesis in liver cancer.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta)
    |
    HIF1A overexpression • HIF1A expression
    15d
    Over-expression of Transmembrane Protein 158 Predicts Aggressive Tumor Behavior and Poor Prognosis in Lung Cancer. (PubMed, Anticancer Res)
    TMEM158 is highly expressed in lung cancer, is associated with hypoxia, and promotes EMT and cell migration. These findings suggest TMEM158 as a potential target for lung cancer therapies.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • TMEM158 (Transmembrane Protein 158)
    |
    HIF1A expression
    16d
    Metformin boosts doxorubicin efficacy and increases CD8 + T cell frequency in mouse breast cancer. (PubMed, Clin Transl Oncol)
    Our findings suggest that combining metformin with doxorubicin can enhance the anticancer activity of doxorubicin and decrease its cytotoxicity in a 4T1 breast cancer mouse model.
    Preclinical • Journal
    |
    CD8 (cluster of differentiation 8) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    |
    STAT3 expression • HIF1A expression
    |
    doxorubicin hydrochloride • metformin
    16d
    Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis. (PubMed, Int Immunopharmacol)
    Blocking oxidative stress and lactate metabolic coupling with reactive oxygen species removers and MCT1-specific inhibitors, respectively, could effectively suppress metastasis in colorectal cancer. These findings suggest that targeting the lactate metabolic coupling between tumor cells and CAFs will offer a new strategy to combat colorectal cancer.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    17d
    Hypoxia-dependent recruitment of error-prone DNA polymerases to genome replication. (PubMed, Oncogene)
    Our results suggest that the tumor microenvironment can lead the cell to forgo, to some extent, the fast and accurate canonical DNA polymerases, for the more flexible and robust, but low-fidelity TLS DNA polymerases. This might endow cancer cells with resilience to overcome replication stress, and mutability to escape the immune system and chemotherapeutic drugs.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • PCNA (Proliferating cell nuclear antigen)
    |
    HIF1A expression • PCNA expression
    17d
    Carvacrol potentiates immunity and sorafenib anti-cancer efficacy by targeting HIF-1α/STAT3/ FGL1 pathway: in silico and in vivo study. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    CVR/SOR is a powerful combination for tumor repression and enhancing SOR efficiency in HCC by modulating FGL1. Moreover, CVR/SOR might exert the aforementioned effects through HIF-1α/STAT3/FGL1 pathway.
    Preclinical • Journal
    |
    JAK2 (Janus kinase 2) • CD8 (cluster of differentiation 8) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CREBBP (CREB binding protein) • FGL1 (Fibrinogen Like 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    |
    HIF1A expression
    |
    sorafenib
    18d
    Anti-VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis. (PubMed, J Pathol)
    © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
    |
    HIF1A expression • VEGFA expression
    18d
    HIF-1α Activates Hypoxia-Induced MXRA5 Expression in the Progression of Ovarian Cancer. (PubMed, J Environ Pathol Toxicol Oncol)
    MXRA5 expression was induced by HY and had prognostic performance in OV. Knockdown of MXRA5 can inhibit proliferation and invasion in OV cells caused by HIF-1α, revealing that MXRA5 is one potential targets for tumor HY regulation in OV.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    19d
    Fusion of breast cancer MCF-7 cells with mesenchymal stem cells rearranges interallelic gene expression and enhances cancer malignancy. (PubMed, Biochem Biophys Res Commun)
    Allele-specific expression analysis of the fused cells indicated that MSC allele-derived HIF1A efficiently induces the expression of glycolysis-related genes in the MCF-7 allele. These findings indicate that the reorganization of gene expression by combining MSCs and MCF-7 alleles resulted in the predominant expression of glycolysis-related genes and increased malignancy in the fused cells.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    21d
    Engineered bacterium-metal-organic framework biohybrids for boosting radiotherapy with multiple effects. (PubMed, Biomaterials)
    Under these multiple cascaded effects, the radiosuppressive tumor microenvironment was significantly reshaped, thus potentiating the radiosentization of SO@Hf-MOF-Pt and remarkably amplifying the therapeutic outcomes of radiotherapy. The designed biohybrid SO@Hf-MOF-Pt represented promising prospects in sensitizing radiotherapy via bacterium-based metabolic regulation.
    Journal
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    LDHA (Lactate dehydrogenase A) • HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    22d
    Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration. (PubMed, Biol Open)
    Finally, the Review underscores the importance of understanding the interplay between drug sequestration, lysosomal functions, nutrient depletion, and MDR1 gene modulation. It suggests innovative strategies, including structural modifications and nanotechnology, as promising approaches to overcoming drug resistance in cancer therapy.
    Review • Journal
    |
    mTOR (Mechanistic target of rapamycin kinase) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    22d
    m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia. (PubMed, J Nanobiotechnology)
    Mechanistically, the circHIF1α interacted with the KH domain of IGF2BP3 in an m6A-modified manner, which mediated DNA damage to arrest the cells at the G1/S phase through the interaction between the regulator of Chromosome Condensation 2 (RCC2) and γ-H2AX protein. Exosomal circHIF1α is a unique therapeutic target for bacterial infection since this work highlights its critical function in fighting bacterial infection.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3)
    |
    HIF1A expression
    22d
    Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis. (PubMed, Sci Rep)
    Cell migration: mock: p = 0.004, and control siRNA: p = 0.014). In conclusion, this study suggests that APOBEC3B may be a new potential therapeutic target for endometriosis.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CASP8 (Caspase 8) • APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B) • APOB (Apolipoprotein B)
    |
    PIK3CA expression • HIF1A expression
    23d
    MOGAT3-Mediated DAG Accumulation Drives Acquired Resistance to Anti-BRAF/EGFR Therapy in BRAFV600E-Mutant Metastatic Colorectal Cancer. (PubMed, J Clin Invest)
    Intriguingly, reducing intratumoral DAG by fenofibrate or Pf-06471553 restores the antitumor efficacy of encorafenib/cetuximab on resistant BRAFV600E-mutant mCRC, interrupted PKCα-CRAF-MEK-ERK signaling. These findings reveal the critical metabolite DAG as a modulator of encorafenib/cetuximab efficacy in BRAFV600E-mutant mCRC, suggesting that fenofibrate may prove beneficial for resistant BRAFV600E-mutant mCRC patients.
    Preclinical • Journal • Metastases
    |
    EGFR (Epidermal growth factor receptor) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase)
    |
    BRAF V600E • EGFR mutation • BRAF V600 • HIF1A expression
    |
    Erbitux (cetuximab) • Braftovi (encorafenib)
    24d
    Electroacupuncture improves cognitive function by modulating hippocampal lactate-mediated HIF-1α signaling pathway and inhibiting inflammation response in vascular dementia rats (PubMed, Zhen Ci Yan Jiu)
    EA stimulation of EX-HN1 and GB20 can improve the cognitive function in VD rats, which may be related to its functions in reducing Lac content, regulating the expression of HIF-1α pathway related proteins, and inhibiting inflammatory responses in the hippocampus tissue.
    Preclinical • Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RELA (RELA Proto-Oncogene)
    |
    HIF1A expression • RELA expression
    25d
    Transarterial Embolization Using an Inorganic Phosphate Binder Modulates Immunity and Angiogenesis-related Factors in a Rat Model of Liver Cancer. (PubMed, J Vasc Interv Radiol)
    S-TAE inhibited the expression of PD-L1 and VEGFα, thereby activated anti-tumor immunity and suppressing tumor angiogenesis. All the findings reveal the biology of tumors under low Pi stress and suggest the potential therapeutic value of S-TAE.
    Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • TGFB1 (Transforming Growth Factor Beta 1)
    |
    PD-L1 expression • HIF1A expression
    25d
    A novel lineage-tracing tool reveals that hypoxic tumor cells drive tumor relapse after radiotherapy. (PubMed, Radiother Oncol)
    Collectively, our data provide clear evidence that the hypoxic cells drive tumor relapse after irradiation.
    Journal • Tumor cell
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    26d
    HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis. (PubMed, J Biochem Mol Toxicol)
    Our findings demonstrated that the HIF1A/PCDH7 axis suppressed LUAD anoikis by promoting FA synthesis and metabolism. The FA synthesis pathway might be a key pathway regulated by PCDH7 in LUAD anoikis.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CASP3 (Caspase 3) • FAS (Fas cell surface death receptor) • FASN (Fatty acid synthase) • ACACA (Acetyl-CoA Carboxylase Alpha) • PCDH7 (Protocadherin 7)
    |
    HIF1A expression
    26d
    A novel quinazoline derivative exhibits potent anticancer cytotoxicity via apoptosis and inhibition of angiogenesis in DMBA-induced mammary gland carcinoma. (PubMed, J Biochem Mol Toxicol)
    Moreover, BBAP-8 fostered apoptosis, when evaluated through BCL-2, BAX, Caspase-8, and Caspase-3. Based on research findings, this implies that BBAP-8 activates FIH-1 and can be effective in chemotherapeutic treatment of mammary gland carcinoma.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • SLC2A1 (Solute Carrier Family 2 Member 1)
    |
    HIF1A expression
    26d
    TME-responsive nanoplatform for multimodal imaging-guided synergistic precision therapy of esophageal cancer via inhibiting HIF-1α signal pathway. (PubMed, J Control Release)
    In summary, we presented a novel nanoplatform for imaging-guided synergistic therapy in EC, which demonstrated excellent anti-tumor growth and metastasis capabilities, along with favorable biocompatibility. This study laid the groundwork for developing innovative theranostic strategies for EC.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • MMP9 (Matrix metallopeptidase 9) • SLC2A1 (Solute Carrier Family 2 Member 1)
    |
    HIF1A expression
    26d
    Resveratrol enhances sensitivity of renal cell carcinoma to tivozanib: An in-vitro study. (PubMed, Tissue Cell)
    Considering that resveratrol can increase the apoptosis of cancer cells alone and in combination with tivozanib and prevent the proliferation of cancer cells and also reduce the side effects of tivozanib, we suggest that resveratrol as a potential bioactive molecule can be used in treatment of kidney cancer should be used in combination with tivozanib.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • VEGFC (Vascular Endothelial Growth Factor C) • KLK3 (Kallikrein-related peptidase 3)
    |
    CDH1 expression • HIF1A expression
    |
    Fotivda (tivozanib)
    26d
    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis. (PubMed, Phytomedicine)
    We observe that HIF-1α/HO-1 axis is the crucial factor in SHK-induced OS ferroptosis. Importantly, we demonstrate that HIF-1α is indirectly regulated by MitoROS rather than SHK bound directly to HIF-1α. Our research suggest that SHK is a potential drug candidate for OS treatment and may help in identifying novel therapeutic targets for OS.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11)
    |
    HIF1A expression • SLC7A11 expression
    28d
    Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer. (PubMed, J Mol Med (Berl))
    HIF-1α induced ERβ gene transcription and protein expression in hypoxic cells via binding to HRE in the ESR2 promoter. The suppression of HIF-1α and ERβ both in vitro and in vivo effectively reduced the NSCLC tumor growth.
    Journal
    |
    ER (Estrogen receptor) • HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A overexpression • HIF1A expression
    |
    fulvestrant
    28d
    PTGES is involved in myofibroblast differentiation via HIF-1α-dependent glycolysis pathway. (PubMed, J Cell Mol Med)
    Targeting PGE2 signalling in PTGES-overexpressing cells by a PTGES inhibitor reduced α-SMA expression. In conclusion, the results of this study demonstrate that PTGES increases the expression of myofibroblast marker via HIF-1α-dependent glycolysis and contributes to myofibroblast differentiation.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • IL13 (Interleukin 13) • IL4 (Interleukin 4) • PTGES (Prostaglandin E Synthase)
    |
    HIF1A expression
    29d
    Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer. (PubMed, Front Oncol)
    It also examined how natural drugs and noncoding RNAs affect various biological processes in BC cells through the regulation of the non-metabolic enzyme functions of PKM2. The findings provide valuable insights for improving the prognosis and developing targeted therapies for BC in the coming years.
    Review • Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3) • PKM (Pyruvate Kinase M1/2)
    |
    HIF1A expression
    30d
    Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB. (PubMed, Int J Mol Sci)
    In patient samples, adenoma patients exhibited increased expression of genes associated with the tumor immune microenvironment, such as IL6ST, collagen family members, and CRC transition markers, such as GLI3 and PIEZO2, in CARD11+ adenoma patients. Carcinoma patients showed a dramatic increase in the expression of MAPK8IP2 in CARD11+ carcinoma patients alongside other cancer-related genes, including EMB, EPHB6, and CPEB4.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CARD11 (Caspase Recruitment Domain Family Member 11) • SPP1 (Secreted Phosphoprotein 1) • EP300 (E1A binding protein p300) • MALT1 (MALT1 Paracaspase) • CCL2 (Chemokine (C-C motif) ligand 2) • GLI3 (GLI Family Zinc Finger 3) • KDM5A (Lysine Demethylase 5A) • CCL22 (C-C Motif Chemokine Ligand 22) • IL1RN (Interleukin 1 receptor antagonist) • IL6ST (Interleukin 6 Signal Transducer) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • CXCL3 (C-X-C Motif Chemokine Ligand 3) • DUSP1 (Dual Specificity Phosphatase 1) • MAPK8IP2 (Mitogen-Activated Protein Kinase 8 Interacting Protein 2)
    |
    HIF1A expression
    1m
    PAARH promotes M2 macrophage polarization and immune evasion of liver cancer cells through VEGF protein. (PubMed, Int J Biol Macromol)
    PAARH enhances the immune evasion capability of liver cancer cells by upregulating VEGF to promote M2 macrophage polarization, suggesting that PAARH may serve as a new therapeutic target for liver cancer.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • VEGFA (Vascular endothelial growth factor A) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • PD-L2 (Programmed Cell Death 1 Ligand 2)
    |
    VEGFA overexpression • HIF1A expression • VEGFA expression
    1m
    ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis. (PubMed, Cell Oncol (Dordr))
    These findings collectively suggest that ALKBH4 acts as a tumor suppressor and holds therapeutic potential for hypoxic tumors.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    HIF1A expression
    1m
    LncRNA-NEAT1 facilitates autophagy to boost pemetrexed resistance in lung adenocarcinoma via the mir-379-3p/HIF1A pathway. (PubMed, Hum Exp Toxicol)
    Our study illuminates the role of lncRNA-NEAT1 in LUAD, where it mediates resistance to PEM through the activation of autophagy via the miR-379-3p/HIF1A axis. This work paves the way for new therapeutic strategies for managing PEM resistance in LUAD patients.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • BECN1 (Beclin 1)
    |
    HIF1A expression
    |
    pemetrexed
    1m
    Cell cycle inhibitors activate hypoxia-induced DDX41-STING pathway to mediate anti-tumor immune response in liver cancer. (PubMed, JCI Insight)
    We demonstrated that Paclitaxel (microtubule stabilizer), Palbociclib (cyclin dependent kinase 4/6 inhibitor), AZD1152 and GSK1070916 (aurora kinase B inhibitors) have anti-cancer functions beyond arresting cell cycle. We observed a trend that Paclitaxel suppressed STINGWT HCC more effectively than STINGKO HCC, suggesting that STING might contribute to the anti-tumor effects of Paclitaxel. Our study revealed the immune-mediated tumor-suppressing properties of cell cycle inhibitors and suggested combined treatment with immunotherapy as a potential therapeutic approach.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • STING (stimulator of interferon response cGAMP interactor 1) • DDX41 (DEAD-Box Helicase 41) • AURKB (Aurora Kinase B)
    |
    HIF1A expression
    |
    Ibrance (palbociclib) • paclitaxel • NMI-900 • barasertib (AZD1152)
    1m
    HIF-1α knockdown suppresses breast cancer metastasis via epithelial mesenchymal transition Abrogation. (PubMed, Heliyon)
    The findings of this study demonstrate that HIF-1α knockdown effectively inhibits lung metastasis of 4T1 cells both in vitro and in vivo by suppressing EMT. These results underscore a promising new approach for managing breast cancer metastasis.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CDH1 (Cadherin 1) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9)
    |
    CDH1 expression • HIF1A expression • VIM expression
    1m
    AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma. (PubMed, Cancer Gene Ther)
    Our data revealed that mice receiving combination suicide gene therapy exhibited reduced expression of HIF-1α ( ~ 4-fold vs. Mock, p < 0.001), with a significant reduction in tumor growth when compared to mock-treated animals. These findings underscore the therapeutic potential of downregulating HIF-1α during suicide gene therapy for HCC.
    Journal • Gene therapy
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • MIR199A1 (MicroRNA 199a-1) • MIR199A (MicroRNA 199a)
    |
    HIF1A expression • miR-199a overexpression
    1m
    Effect and mechanism of novel HDAC inhibitor ZDLT-1 in colorectal cancer by regulating apoptosis and inflammation. (PubMed, Int Immunopharmacol)
    ZDLT-1 as HDAC inhibitor could suppresses CRC cell growth in vivo and in vitro by triggering HIF-1α/Caspase-3/Caspase-9 pathway in promoting apoptosis, and triggering NF-κB/GSDMD/GSDME pathway in inhibiting tumor inflammation. Our results propose dehydroharmine derivative ZDLT-1 as a promising therapeutic small molecular agent for CRC.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • ANXA5 (Annexin A5) • GSDME (Gasdermin E)
    |
    HIF1A expression
    1m
    Anticancer potential of isoalantolactone in testicular cancer: an analysis of cytotoxicity, apoptosis, and signaling pathways. (PubMed, Aging (Albany NY))
    Moreover, IATL induced ferroptosis by modulating expression levels of GPX4, xCT, NRF2, and HO-1. Our findings shed light on IATL's multifaceted anticancer mechanisms, emphasizing its potential as a therapeutic candidate for testicular cancer.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • GPX4 (Glutathione Peroxidase 4) • ANXA5 (Annexin A5)
    |
    HIF1A expression
    1m
    Clinical implications of activation of the LIMD1-VHL-HIF1α pathway during head-&-neck squamous cell carcinoma development. (PubMed, Indian J Med Res)
    The H/M expression of HIF1α/VEGF proteins and reduced VHL expression was associated with poor clinical outcomes. Interpretation & conclusions The results of this study showed differential regulation of the LIMD1-VHL-HIF1α pathway in HPV positive and negative HNSCC samples, illustrating the molecular distinctiveness of these two groups.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • VHL (von Hippel-Lindau tumor suppressor)
    |
    HIF1A expression • VEGFA expression