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our Premium Content: News alerts, weekly reports and conference plannersBIOMARKER:
HER-2 negative + CLDN18.2 positive
i
Other names: ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; CLDN18, Claudin-18, Surfactant, Pulmonary Associated Protein J, Surfactant Associated 5, SFTA5, SFTPJ
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News alerts, weekly reports and conference planners
27d
Immune checkpoint inhibitors in advanced gastroesophageal adenocarcinoma: a series of patient-level meta-analyses in different programmed death-ligand 1 subgroups. (PubMed, ESMO Open)
In PD-L1low HER-2 negative GEAC, the benefit of first-line ICI is modest, yet significant. Further translational work is warranted to better select patients who could benefit from immunotherapy in this setting. Meanwhile, alternative therapeutic options such as zolbetuximab in Claudin18.2-positive disease must be taken into account.
Clinical • Journal • Checkpoint inhibition • Metastases
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HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CLDN18 (Claudin 18)
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HER-2 negative • PD-L1-L • HER-2 negative + CLDN18.2 positive
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Vyloy (zolbetuximab-clzb)
4ms
Osemitamab (TST001) plus nivolumab and CAPOX as the first-line therapy for the patients with advanced G/GEJ cancer (TranStar102) (ESMO 2024)
Updated data indicate that the combination of TST001 plus nivolumab and CAPOX as the 1L treatment for patients with G/GEJ cancer is safe and well tolerated with very encouraging anti-tumor activities, especially for patients with high/medium CLDN18.2 expression when cross comparing to historical data.
Clinical • PD(L)-1 Biomarker • IO biomarker • Metastases
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HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CLDN18 (Claudin 18)
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PD-L1 expression • HER-2 negative • CLDN18.2 expression • CLDN18.2 positive • HER-2 negative + CLDN18.2 positive
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PD-L1 IHC 28-8 pharmDx • Claudin18.2 IHC 14G11 pharmDx
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Opdivo (nivolumab) • osemitamab (TST001)
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