HER-2 underexpression

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Entrez ID:

2064

Related biomarkers:

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HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	cyclophosphamide + albumin-bound paclitaxel + epirubicin Sensitive: C3 – Early Trials Nanomedicine - 2 weeks (New C3) cyclophosphamide + albumin-bound paclitaxel + epirubicin Sensitive : C3 Nanomedicine - 2wk	cyclophosphamide + albumin-bound paclitaxel + epirubicin Sensitive: C3 – Early Trials Nanomedicine - 2 weeks cyclophosphamide + albumin-bound paclitaxel + epirubicin Sensitive : C3 Nanomedicine - 2 weeks - (New C3)
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	fam-trastuzumab deruxtecan-nxki Sensitive: A1 - Approval fam-trastuzumab deruxtecan-nxki Sensitive : C1	fam-trastuzumab deruxtecan-nxki Sensitive: A1 - Approval fam-trastuzumab deruxtecan-nxki Sensitive : C1
HER-2 underexpression	Hormone Receptor Positive Breast Cancer	HER-2 underexpression	Hormone Receptor Positive Breast Cancer	fam-trastuzumab deruxtecan-nxki Sensitive: B - Late Trials fam-trastuzumab deruxtecan-nxki Sensitive : C1	fam-trastuzumab deruxtecan-nxki Sensitive: B - Late Trials fam-trastuzumab deruxtecan-nxki Sensitive : C1
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	eribulin mesylate Sensitive: B - Late Trials eribulin mesylate Sensitive : B	eribulin mesylate Sensitive: B - Late Trials eribulin mesylate Sensitive : B
HER-2 underexpression	Gastroesophageal Junction Adenocarcinoma	HER-2 underexpression	Gastroesophageal Junction Adenocarcinoma	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1
HER-2 underexpression	Gastric Cancer	HER-2 underexpression	Gastric Cancer	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1
HER-2 underexpression	Triple Negative Breast Cancer	HER-2 underexpression	Triple Negative Breast Cancer	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1	fam-trastuzumab deruxtecan-nxki Sensitive: C1 - Off-label fam-trastuzumab deruxtecan-nxki Sensitive : C1
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	ado-trastuzumab emtansine Sensitive: C2 – Inclusion Criteria ado-trastuzumab emtansine Sensitive : C2	ado-trastuzumab emtansine Sensitive: C2 – Inclusion Criteria ado-trastuzumab emtansine Sensitive : C2
HER-2 underexpression	Solid Tumor	HER-2 underexpression	Solid Tumor	IKS014 Sensitive: C2 – Inclusion Criteria IKS014 Sensitive : C2	IKS014 Sensitive: C2 – Inclusion Criteria IKS014 Sensitive : C2
HER-2 underexpression	Solid Tumor	HER-2 underexpression	Solid Tumor	KN046 + KN026 Sensitive: C3 – Early Trials KN046 + KN026 Sensitive : C3	KN046 + KN026 Sensitive: C3 – Early Trials KN046 + KN026 Sensitive : C3
HER-2 underexpression	Lung Adenocarcinoma	HER-2 underexpression	Lung Adenocarcinoma	ado-trastuzumab emtansine Sensitive: C3 – Early Trials ado-trastuzumab emtansine Sensitive : C3	ado-trastuzumab emtansine Sensitive: C3 – Early Trials ado-trastuzumab emtansine Sensitive : C3
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	SYD985 Sensitive: C3 – Early Trials SYD985 Sensitive : C3	SYD985 Sensitive: C3 – Early Trials SYD985 Sensitive : C3
HER-2 underexpression	Hormone Receptor Positive Breast Cancer	HER-2 underexpression	Hormone Receptor Positive Breast Cancer	SYD985 Sensitive: C3 – Early Trials SYD985 Sensitive : C3	SYD985 Sensitive: C3 – Early Trials SYD985 Sensitive : C3
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	MRG002 Sensitive: C3 – Early Trials MRG002 Sensitive : C3	MRG002 Sensitive: C3 – Early Trials MRG002 Sensitive : C3
HER-2 underexpression	Ovarian Cancer	HER-2 underexpression	Ovarian Cancer	olaparib + niraparib + SYD985 Sensitive: D – Preclinical olaparib + niraparib + SYD985 Sensitive : D	olaparib + niraparib + SYD985 Sensitive: D – Preclinical olaparib + niraparib + SYD985 Sensitive : D
HER-2 underexpression	Colorectal Cancer	HER-2 underexpression	Colorectal Cancer	SAR446309 Sensitive: D – Preclinical SAR446309 Sensitive : D	SAR446309 Sensitive: D – Preclinical SAR446309 Sensitive : D
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	SAR443216 Sensitive: D – Preclinical SAR443216 Sensitive : D	SAR443216 Sensitive: D – Preclinical SAR443216 Sensitive : D
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	XMT-2056 Sensitive: D – Preclinical XMT-2056 Sensitive : D	XMT-2056 Sensitive: D – Preclinical XMT-2056 Sensitive : D
HER-2 underexpression	Gastric Cancer	HER-2 underexpression	Gastric Cancer	XMT-2056 Sensitive: D – Preclinical XMT-2056 Sensitive : D	XMT-2056 Sensitive: D – Preclinical XMT-2056 Sensitive : D
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	disitamab vedotin + ABBV-IMAB-TJC4 Sensitive: D – Preclinical disitamab vedotin + ABBV-IMAB-TJC4 Sensitive : D	disitamab vedotin + ABBV-IMAB-TJC4 Sensitive: D – Preclinical disitamab vedotin + ABBV-IMAB-TJC4 Sensitive : D
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	trastuzumab-pkrb Sensitive: D – Preclinical trastuzumab-pkrb Sensitive : D	trastuzumab-pkrb Sensitive: D – Preclinical trastuzumab-pkrb Sensitive : D
HER-2 underexpression	Breast Cancer	HER-2 underexpression	Breast Cancer	trastuzumab + durvalumab Sensitive: D – Preclinical trastuzumab + durvalumab Sensitive : D	trastuzumab + durvalumab Sensitive: D – Preclinical trastuzumab + durvalumab Sensitive : D

HER-2 underexpression

Associations