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    DRUG:

    porustobart (HBM4003)

    i
    Other names: HBM4003, HBM 4003, HBM-4003
    Associations

    News

    Trials
    Company:
    Harbour BioMed
    Drug class:
    CTLA4 inhibitor, Treg cell depleter
    Related drugs:
    Associations

    News

    Trials
    1year
    A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=65, Completed, Harbour BioMed US, Inc. | Active, not recruiting --> Completed | Trial primary completion date: Sep 2022 --> Jan 2023
    Trial completion • Trial primary completion date • Metastases
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • BRAF V600
    |
    porustobart (HBM4003)
    almost2years
    A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=65, Active, not recruiting, Harbour BioMed US, Inc. | Trial primary completion date: Jun 2022 --> Sep 2022
    Trial primary completion date
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • BRAF V600
    |
    porustobart (HBM4003)
    2years
    A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=65, Active, not recruiting, Harbour BioMed US, Inc. | Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2023 --> Jun 2022
    Enrollment closed • Trial primary completion date
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • BRAF V600
    |
    porustobart (HBM4003)
    almost3years
    A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=52, Recruiting, Harbour BioMed US, Inc. | N=30 --> 52 | Trial completion date: Feb 2022 --> Mar 2023 | Trial primary completion date: Oct 2020 --> Mar 2023
    Clinical • Enrollment change • Trial completion date • Trial primary completion date
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • BRAF V600
    |
    porustobart (HBM4003)
    3years
    A Study to Evaluate Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 Combined With Anti-PD-1 Antibody (clinicaltrials.gov)
    P1, N=66, Not yet recruiting, Harbour BioMed (Guangzhou) Co. Ltd.
    Clinical • New P1 trial • Combination therapy
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • porustobart (HBM4003)