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DRUG:

porustobart (HBM4003)

i
Other names: HBM4003, HBM 4003, HBM-4003
Associations
Company:
Harbour BioMed
Drug class:
CTLA4 inhibitor, Treg cell depleter
Associations
1m
Toripalimab in combination with HBM4003, an anti-CTLA-4 heavy chain-only antibody, in advanced melanoma and other solid tumors: an open-label phase I trial. (PubMed, J Immunother Cancer)
HBM4003 0.3 mg/kg plus toripalimab 240 mg every 3 week demonstrated manageable safety in solid tumors and no new safety signal. Limited data demonstrated promising antitumor activity, especially in PD-1 treatment-naïve mucosal melanoma.
P1 data • Journal • Combination therapy • PD(L)-1 Biomarker • IO biomarker • Metastases
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CD4 (CD4 Molecule)
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Loqtorzi (toripalimab-tpzi) • porustobart (HBM4003)
over1year
A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=65, Completed, Harbour BioMed US, Inc. | Active, not recruiting --> Completed | Trial primary completion date: Sep 2022 --> Jan 2023
Trial completion • Trial primary completion date • Metastases
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BRAF (B-raf proto-oncogene)
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BRAF mutation • BRAF V600
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porustobart (HBM4003)
over2years
A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=65, Active, not recruiting, Harbour BioMed US, Inc. | Trial primary completion date: Jun 2022 --> Sep 2022
Trial primary completion date
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BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF V600
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porustobart (HBM4003)
over2years
A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=65, Active, not recruiting, Harbour BioMed US, Inc. | Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2023 --> Jun 2022
Enrollment closed • Trial primary completion date
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BRAF (B-raf proto-oncogene)
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BRAF mutation • BRAF V600
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porustobart (HBM4003)
over3years
A Study Evaluating the Safety, Tolerance and Anti-tumor Activity of a Study Drug in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=52, Recruiting, Harbour BioMed US, Inc. | N=30 --> 52 | Trial completion date: Feb 2022 --> Mar 2023 | Trial primary completion date: Oct 2020 --> Mar 2023
Clinical • Enrollment change • Trial completion date • Trial primary completion date
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BRAF (B-raf proto-oncogene)
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BRAF mutation • BRAF V600
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porustobart (HBM4003)
over3years
Clinical • New P1 trial • Combination therapy
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PD-L1 (Programmed death ligand 1)
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PD-L1 expression
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Keytruda (pembrolizumab) • porustobart (HBM4003)