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    over2years
    Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia. (PubMed, Br J Haematol)
    Cells expressing GOLGA4-JAK2 demonstrated constitutive activation of JAK/STAT signalling and were sensitive to JAK inhibitors. This study contributes to the diverse collection of JAK2 fusion genes identified in B-ALL and supports the incorporation of JAK inhibitors into treatment strategies to improve outcomes for this subtype.
    Journal
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    JAK2 (Janus kinase 2) • GOLGA4 (Golgin A4)
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    GOLGA4-JAK2 fusion • JAK2 fusion