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    BIOMARKER:

    GOLGA4-JAK2 fusion

    i
    Other names: JTK10, THCYT3, JAK2, Janus Kinase 2, Tyrosine-Protein Kinase JAK2, JAK-2, GOLGA4, Golgi Autoantigen, Golgin Subfamily A, 4, Golgin Subfamily A Member 4, Trans-Golgi P230, ProGolgin-240, Golgin-245, Centrosome-Related Protein F46, Golgin 245, CRPF46
    Entrez ID:
    3717; 2803
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    3years
    Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia. (PubMed, Br J Haematol)
    Cells expressing GOLGA4-JAK2 demonstrated constitutive activation of JAK/STAT signalling and were sensitive to JAK inhibitors. This study contributes to the diverse collection of JAK2 fusion genes identified in B-ALL and supports the incorporation of JAK inhibitors into treatment strategies to improve outcomes for this subtype.
    Journal
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    JAK2 (Janus kinase 2) • GOLGA4 (Golgin A4)
    |
    GOLGA4-JAK2 fusion • JAK2 fusion