^
    10d
    NRG-GY033: Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors (clinicaltrials.gov)
    P2, N=37, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended
    Trial suspension • Combination therapy
    |
    ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    exemestane • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    13d
    To Assess The Patient Preference for Goserelin Microsphere Versus Goserelin Implant in Patients With Prostate Cancer (clinicaltrials.gov)
    P2, N=60, Recruiting, The First Affiliated Hospital of Xiamen University
    New P2 trial
    |
    goserelin acetate • Baituowei (goserelin acetate sustained-release microspheres for injection)
    14d
    Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer (clinicaltrials.gov)
    P1, N=14, Recruiting, Roswell Park Cancer Institute | Not yet recruiting --> Recruiting
    Enrollment open • Metastases
    |
    Eligard (leuprolide acetate) • Viadur (leuprorelin implant)
    16d
    The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (clinicaltrials.gov)
    P2, N=180, Recruiting, Weill Medical College of Cornell University | Trial primary completion date: Feb 2025 --> Dec 2025
    Trial primary completion date
    |
    Eligard (leuprolide acetate)
    16d
    Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer (clinicaltrials.gov)
    P2, N=104, Recruiting, Fudan University | Trial primary completion date: Mar 2024 --> Mar 2025
    Trial primary completion date
    |
    letrozole • megestrol
    16d
    Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect (clinicaltrials.gov)
    P=N/A, N=94, Recruiting, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Not yet recruiting --> Recruiting
    Enrollment open
    |
    leuprolide acetate for depot suspension
    1m
    PEGASUS: Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer (clinicaltrials.gov)
    P3, N=885, Active, not recruiting, European Organisation for Research and Treatment of Cancer - EORTC | Trial completion date: Jun 2024 --> Jun 2026 | Trial primary completion date: Jun 2024 --> Nov 2023
    Trial completion date • Trial primary completion date • Metastases
    |
    Firmagon (degarelix)
    1m
    Effects of Triptorelin Pamoate 6-month When Given to Adult Chinese Participants With Advanced Cancer in the Prostate (clinicaltrials.gov)
    P3, N=195, Active, not recruiting, Ipsen | Recruiting --> Active, not recruiting
    Enrollment closed • Metastases
    |
    triptorelin
    1m
    YATAGARASU: A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma (clinicaltrials.gov)
    P2, N=31, Active, not recruiting, Janssen Pharmaceutical K.K. | Trial completion date: May 2024 --> Sep 2025
    Trial completion date • Combination therapy • Metastases
    |
    AR (Androgen receptor)
    |
    AR positive • AR expression
    |
    Erleada (apalutamide) • goserelin acetate
    1m
    Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer (clinicaltrials.gov)
    P2, N=70, Not yet recruiting, Ohio State University Comprehensive Cancer Center
    New P2 trial
    |
    Eligard (leuprolide acetate) • Orgovyx (relugolix)
    2ms
    Adaptive Stereotactic Body Radiation Therapy to the Prostate and Pelvic Nodes With Simultaneous Integrated Boost to the MR-detected Nodule for Patients With High-risk and Unfavorable Intermediate-risk Prostate Cancer (clinicaltrials.gov)
    P=N/A, N=25, Recruiting, Washington University School of Medicine | Trial completion date: Jan 2030 --> Jan 2031 | Trial primary completion date: Apr 2025 --> Apr 2026
    Trial completion date • Trial primary completion date
    |
    goserelin acetate
    2ms
    Transcriptome profiling reveals superovulation with the gonadotropin-releasing hormone agonist trigger impaired embryo implantation in mice. (PubMed, Front Endocrinol (Lausanne))
    Mice in the superovulation (PG) group were administered 7.5 IU of PMSG, followed by the injection of 3.5 μg of GnRHa (Leuprorelin) 48 h later, while mice in the control group (CTR) mated naturally...The transcriptome analysis showed that superphysiological estrogen led to a response of the uterus to a high estrogen signal, resulting in abnormal endometrium and extracellular matrix remodeling and up-regulation of ion transport and inflammation-related genes. Our findings suggest that a combination of PMSG and GnRHa trigger impaired embryo implantation in mice, as the excessive uterine response to superphysiological estrogen levels can lead to the change of gene expression related to endometrial remodeling, abnormal expression of uterine ion transport genes and excessive immune-related genes.
    Preclinical • Journal
    |
    LIF (LIF Interleukin 6 Family Cytokine)
    |
    leuprolide acetate for depot suspension
    2ms
    Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer (clinicaltrials.gov)
    P1, N=14, Not yet recruiting, Roswell Park Cancer Institute
    New P1 trial • Metastases
    |
    Eligard (leuprolide acetate) • Viadur (leuprorelin implant)
    2ms
    Effects of Triptorelin Pamoate 6-month When Given to Adult Chinese Participants With Advanced Cancer in the Prostate (clinicaltrials.gov)
    P3, N=195, Recruiting, Ipsen | Trial completion date: Jul 2024 --> Oct 2024 | Trial primary completion date: Jul 2024 --> Oct 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    triptorelin
    2ms
    ADOPT: Androgen Deprivation Therapy for Oligo-recurrent Prostate Cancer in Addition to radioTherapy (clinicaltrials.gov)
    P3, N=280, Recruiting, University Medical Center Groningen | Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024
    Trial completion date • Trial primary completion date
    |
    Eligard (leuprolide acetate)
    2ms
    LIBELULA: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Debio 4326 in Pediatric Participants Receiving Gonadotropin-Releasing Hormone Agonist Therapy for Central Precocious Puberty (clinicaltrials.gov)
    P3, N=53, Recruiting, Debiopharm International SA | Not yet recruiting --> Recruiting
    Enrollment open
    |
    triptorelin
    2ms
    Aurora Test for ART Donor Patients (AURORA-Donor) (clinicaltrials.gov)
    P=N/A, N=160, Recruiting, Fertiga, Belgium
    New trial
    2ms
    THUNDER: Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular Tracers (clinicaltrials.gov)
    P2/3; N=493; Recruiting; Sponsor:Cancer Research Antwerp
    New P2/3 trial
    |
    Decipher Prostate Cancer Test
    |
    docetaxel • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • triptorelin • goserelin acetate • Firmagon (degarelix)
    3ms
    Hormone Therapy and Intensity-Modulated Radiation Therapy in Treating Patients With Metastatic Prostate Cancer (clinicaltrials.gov)
    P2, N=29, Active, not recruiting, City of Hope Medical Center | Trial completion date: Dec 2023 --> Dec 2024
    Trial completion date • Metastases
    |
    Eligard (leuprolide acetate) • bicalutamide • goserelin acetate • Viadur (leuprorelin implant)
    3ms
    NRG-GY033: Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors (clinicaltrials.gov)
    P2, N=37, Recruiting, National Cancer Institute (NCI) | Initiation date: Oct 2024 --> Feb 2024
    Trial initiation date • Combination therapy
    |
    ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    exemestane • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    3ms
    ROSE: Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment (clinicaltrials.gov)
    P=N/A, N=419, Recruiting, Ipsen | Trial primary completion date: Jun 2024 --> Dec 2025
    Trial primary completion date • HEOR
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • BRCA (Breast cancer early onset)
    |
    BRCA1 mutation • HR positive • HER-2 negative • HR positive + HER-2 negative • BRCA mutation • PTEN mutation + HR positive
    |
    triptorelin
    3ms
    A Study of Leuprolide Acetate Depot in Children With Central Precocious Puberty (clinicaltrials.gov)
    P4, N=80, Recruiting, Takeda | Trial completion date: Apr 2024 --> May 2025 | Trial primary completion date: Jan 2024 --> May 2025
    Trial completion date • Trial primary completion date
    |
    leuprolide acetate for depot suspension
    3ms
    SATURN: Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer (clinicaltrials.gov)
    P2, N=28, Active, not recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Jan 2025 --> Jan 2026 | Trial primary completion date: Jan 2024 --> Jan 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    abiraterone acetate • Eligard (leuprolide acetate) • Erleada (apalutamide) • Viadur (leuprorelin implant)
    3ms
    RecoverPC: Relugolix vs GnRH Agonist in Quality of Life (clinicaltrials.gov)
    P2, N=110, Recruiting, Dana-Farber Cancer Institute | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Orgovyx (relugolix) • leuprolide acetate for depot suspension
    3ms
    A Study Called AWARENESS Using Data From Men in Alberta to Observe Treatment Patterns for Metastatic Castration-sensitive Prostate Cancer (clinicaltrials.gov)
    P=N/A, N=960, Completed, Bayer | Active, not recruiting --> Completed
    Trial completion
    |
    docetaxel • Xtandi (enzalutamide capsule) • abiraterone acetate • Eligard (leuprolide acetate) • triptorelin • goserelin acetate • cyproterone acetate
    3ms
    NRG-GY033: Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors (clinicaltrials.gov)
    P2, N=37, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting
    Enrollment open
    |
    ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    exemestane • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    3ms
    Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine (clinicaltrials.gov)
    P4, N=126, Completed, Children's Hospital of Fudan University | Recruiting --> Completed
    Trial completion
    |
    megestrol • leuprolide acetate for depot suspension
    3ms
    Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support (clinicaltrials.gov)
    P4, N=75, Completed, Alexandria University | Recruiting --> Completed
    Trial completion
    |
    triptorelin
    3ms
    Pharmacodynamic Study Goserelin 3.6mg Injection Administered Subcutaneously in Premenopausal Patients With Breast Cancer (clinicaltrials.gov)
    P3, N=68, Recruiting, Eurofarma Laboratorios S.A. | Trial completion date: Jun 2025 --> Jan 2025 | Trial primary completion date: Nov 2023 --> Sep 2024
    Trial completion date • Trial primary completion date
    |
    ER (Estrogen receptor)
    |
    ER positive
    |
    goserelin acetate
    3ms
    ESCALATE: Neoadjuvant Chemotherapy With or Without GnRH Agonist for Premenopausal Triple-negative Early Breast Cancer Patients (clinicaltrials.gov)
    P2, N=124, Not yet recruiting, National Taiwan University Hospital
    New P2 trial
    |
    docetaxel • cyclophosphamide • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
    4ms
    Real-life Evaluation of the Effect of ADT in Prostate Cancer Patients in Asia (READT Asia Study) (clinicaltrials.gov)
    P=N/A, N=300, Active, not recruiting, Chinese University of Hong Kong | Recruiting --> Active, not recruiting | N=600 --> 300
    Enrollment closed • Enrollment change
    |
    Eligard (leuprolide acetate) • Firmagon (degarelix)
    4ms
    Retrospective Study to Assess Real-Life Use of The Long Acting GnRH Agonist as Prostate Cancer Treatment (clinicaltrials.gov)
    P=N/A, N=237, Completed, Chinese University of Hong Kong
    New trial • Metastases
    4ms
    Estrogen-induced glial IL-1β mediates extrinsic retinal ganglion cell vulnerability in murine Nf1 optic glioma. (PubMed, Ann Clin Transl Neurol)
    In contrast to their male counterparts, female Nf1 mice have increased expression of glial interleukin-1β (IL-1β), which is neurotoxic to RGCs in vitro. Importantly, both IL-1β neutralization and leuprolide-mediated estrogen suppression decrease IL-1β expression and ameliorate RGC dysfunction, providing preclinical proof-of-concept evidence supporting novel neuroprotective strategies for NF1-OPG-induced vision loss.
    Preclinical • Journal
    |
    NF1 (Neurofibromin 1) • IL1B (Interleukin 1, beta)
    |
    leuprolide acetate for depot suspension
    4ms
    REAL6T: A Study to Observe Demography and the Outcome of Prostate Cancer Patients Treated With 6-month Triptorelin Formulation in Italy (clinicaltrials.gov)
    P=N/A, N=300, Recruiting, Ipsen | Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
    Trial completion date • Trial primary completion date
    |
    triptorelin
    4ms
    Zoladex® 10.8 BC RWS (clinicaltrials.gov)
    P=N/A, N=1176, Completed, AstraZeneca | Recruiting --> Completed
    Trial completion • Real-world evidence • Real-world
    |
    HR positive
    |
    goserelin acetate
    4ms
    DEFINE: Dose Escalation For INtraprostatic LEsions (clinicaltrials.gov)
    P2, N=54, Recruiting, Ottawa Hospital Research Institute | Initiation date: Jun 2023 --> Nov 2023 | Not yet recruiting --> Recruiting
    Enrollment open • Trial initiation date
    |
    triptorelin
    5ms
    Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study (clinicaltrials.gov)
    P3, N=250, Enrolling by invitation, Tolmar Inc.
    Trial completion date • Trial primary completion date
    |
    tamoxifen • letrozole • anastrozole • exemestane • Eligard (leuprolide acetate)
    5ms
    LIBELULA: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Debio 4326 in Pediatric Participants Receiving Gonadotropin-Releasing Hormone Agonist Therapy for Central Precocious Puberty (clinicaltrials.gov)
    P3, N=53, Not yet recruiting, Debiopharm International SA
    Trial completion date • Trial initiation date • Trial primary completion date
    |
    triptorelin
    5ms
    RecoverPC: Relugolix vs GnRH Agonist in Quality of Life (clinicaltrials.gov)
    P2, N=110, Not yet recruiting, Dana-Farber Cancer Institute | Initiation date: Aug 2023 --> Jan 2024
    Trial initiation date • HEOR
    |
    Orgovyx (relugolix) • leuprolide acetate for depot suspension
    5ms
    A Study to Evaluate Leuprolide Acetate 45 mg 6-Month Formulation in Children With Central Precocious Puberty (CPP) (clinicaltrials.gov)
    P3, N=45, Completed, AbbVie | Active, not recruiting --> Completed
    Trial completion
    |
    leuprolide acetate for depot suspension
    5ms
    Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors (clinicaltrials.gov)
    P2, N=37, Not yet recruiting, National Cancer Institute (NCI)
    New P2 trial
    |
    ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    exemestane • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    5ms
    LOBSTER: Long-term Better Than Short-term ADT With Salvage RT (clinicaltrials.gov)
    P2/3, N=394, Recruiting, Universitaire Ziekenhuizen KU Leuven | Not yet recruiting --> Recruiting | Trial completion date: Feb 2029 --> Feb 2031 | Trial primary completion date: Feb 2024 --> Feb 2026
    Enrollment open • Trial completion date • Trial primary completion date
    |
    triptorelin