^
    5d
    HYP-OP-RT: Non-inferiority Study Comparing Salvage Pelvic Radiotherapy in 25 Fractions (62.5 Gy/25) Versus 20 Fractions (52.5 Gy/20) for Recurrent Prostate Cancer After Surgery. (clinicaltrials.gov)
    P=N/A, N=434, Not yet recruiting, CHU de Quebec-Universite Laval
    New trial • Head-to-Head
    |
    goserelin acetate
    6d
    The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles (clinicaltrials.gov)
    P4, N=600, Completed, Cairo University | Recruiting --> Completed
    Trial completion
    8d
    RADVAN: Radiotherapy After Prostatectomy for Node Positive Prostate Cancer (clinicaltrials.gov)
    P3, N=374, Active, not recruiting, Sun Yat-sen University
    New P3 trial
    |
    triptorelin • goserelin acetate
    12d
    RATIONAL-PCS: Study of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Patients With Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC) (clinicaltrials.gov)
    P2, N=162, Recruiting, Ontario Clinical Oncology Group (OCOG) | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Eligard (leuprolide acetate)
    14d
    Retrospective analysis of growth hormone effects on growth and adenoma volume in children with pituitary microadenoma. (PubMed, Transl Pediatr)
    Female and male subgroups differed significantly in PAH and BA-CA improvements (P<0.05). Combined GH and leuprorelin enhances linear growth and delayed bone maturation in children with PM and compromised PAH, without promoting tumor growth or sustained IGF-1 elevation.
    Retrospective data • Journal
    |
    IGF1 (Insulin-like growth factor 1)
    |
    leuprolide acetate for depot suspension
    15d
    Evaluation of Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients (clinicaltrials.gov)
    P2, N=98, Not yet recruiting, Mayo Clinic
    New P2 trial
    |
    HR positive
    |
    goserelin acetate
    15d
    PRIAPUS-PCa Study: Stereotactic Body Radiation Therapy (SBRT) and Androgen Deprivation Therapy (ADT) Impact on Sexual Function on Men With Unfavorable Intermediate Risk Prostate Cancer (clinicaltrials.gov)
    P=N/A, N=130, Not yet recruiting, CancerCare Manitoba
    New trial
    |
    goserelin acetate
    21d
    Effect of Education on Treatment Decision Making for Patients With Prostate Cancer on Chronic Hormone Treatments (clinicaltrials.gov)
    P=N/A, N=100, Recruiting, University of Chicago | Trial completion date: Dec 2025 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Dec 2027
    Trial completion date • Trial primary completion date
    27d
    Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. (PubMed, Case Rep Oncol Med)
    A 75-year-old man with mHSPC was treated with Apa and leuprorelin. Apa induced CYP3A4 via the PXR pathway, leading to a sustained DDI with CsA. Careful monitoring is necessary when Apa is coadministered with CYP3A4 substrates.
    Journal
    |
    CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)
    |
    apalutamide • cyclosporine • leuprolide acetate for depot suspension
    29d
    A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants (clinicaltrials.gov)
    P1, N=55, Completed, EMD Serono Research & Development Institute, Inc. | Recruiting --> Completed
    Trial completion
    |
    goserelin acetate
    1m
    COMPASS - COpenhagen MenoPAuSe Study (2025-522558-37-00)
    P1/2, N=200, Not yet recruiting, Region Hovedstaden
    New P1/2 trial
    |
    triptorelin
    1m
    A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care. (PubMed, F S Rep)
    Of the patients treated for their positive BCL6 results, 20 (86%) were treated with leuprolide acetate, 9 (39%) with an aromatase inhibitor, and 1 (4%) was surgically managed with a laparoscopy in preparation for their frozen embryo transfer...The relationship between BCL6 and endometriosis may not be the golden solution to a single marker focus for testing, or for subsequent therapy planning among infertility patients. Clinicians should be cautious in using single marker testing for diagnosing and treating endometriosis in patients without strong additional therapeutic evidence.
    Journal
    |
    BCL6 (B-cell CLL/lymphoma 6)
    |
    leuprolide acetate for depot suspension